This study sought to investigate the association between selective serotonin reuptake inhibitor (SSRI) intake, a history of psychiatric disease, and pregnancy outcomes in a Danish cohort of 57 001 pregnancies. There was no association of SSRI exposure during pregnancy with birth weight or head circumference. However, infants exposed to SSRIs were more likely to have a 5-minute Apgar score of less than 8 and were more likely to be admitted to the neonatal intensive care unit. The results corroborate earlier studies with less control for the potential effects of the underlying disease. However, treatment of depression during pregnancy may be warranted and future studies need to distinguish between individual SSRIs to find the safest medication.