Author Contributions:Dr Scaramuzza had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Mameli, Scaramuzza, Riboni, De Palma, and Zuccotti. Acquisition of data: Mameli and Tadini. Analysis and interpretation of data: Mameli, Scaramuzza, Tadini, and Riboni. Drafting of the manuscript: Mameli and Scaramuzza. Critical revision of the manuscript for important intellectual content: Scaramuzza, Tadini, Riboni, De Palma, and Zuccotti. Administrative, technical, and material support: Mameli, Scaramuzza, Tadini, Riboni, De Palma, and Zuccotti. Study supervision: Mameli.