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Fructose and Oxidized Low-Density Lipoprotein in Pediatric Nonalcoholic Fatty Liver Disease: A Pilot Study

Miriam B. Vos, MD, MSPH; Mary Beth Weber, MPH; Jean Welsh, RN, MPH; Farah Khatoon, MD; Dean P. Jones, PhD; Peter F. Whitington, MD; Craig J. McClain, MD
Arch Pediatr Adolesc Med. 2009;163(7):674-675. doi:10.1001/archpediatrics.2009.93.
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Change in diet is a primary lifestyle modification recommended in the treatment of pediatric nonalcoholic fatty liver disease (NAFLD). However, it is not clear which dietary components are the most important to target. In the United States, the consumption of fructose has increased nearly 50% and, on average, adolescents have a high intake (12% of total daily caloric intake).1 Diets high in fructose are known to increase plasma lipids and oxidative stress,2 both components suspected in NAFLD pathogenesis. Recently, patients with NAFLD were found to consume more fructose compared with matched controls.3 Given this and our previous animal studies,4 we designed a pilot study to evaluate a low-fructose diet in children with NAFLD.

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