Physical activity is increasingly recognized as an important component of health, with effects on physical, mental, and emotional health. There are a number of factors that affect sports participation among adolescents, but one that has not been well explored is chronic health conditions. In this large study of 16- to 20-year-olds from Switzerland, males with chronic conditions were less likely to participate in sports than males without, though among females, there was no effect from having a chronic health condition. Adolescents with chronic health conditions did view this as a barrier, though not the main barrier, to sports participation; lack of time for sports was cited as a barrier for sports participation by many. Encouraging sports participation among all adolescents, including those with chronic conditions, is appropriate.