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Article |

Randomized Controlled Trial of a Pictogram-Based Intervention to Reduce Liquid Medication Dosing Errors and Improve Adherence Among Caregivers of Young Children FREE

H. Shonna Yin, MD, MS; Benard P. Dreyer, MD; Linda van Schaick, MS Ed; George L. Foltin, MD; Cheryl Dinglas, BA; Alan L. Mendelsohn, MD
[+] Author Affiliations

Author Affiliations: New York University School of Medicine and Department of Pediatrics, Bellevue Hospital Center, New York, New York.


Arch Pediatr Adolesc Med. 2008;162(9):814-822. doi:10.1001/archpedi.162.9.814.
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Objective  To evaluate the efficacy of a pictogram-based health literacy intervention to decrease liquid medication administration errors by caregivers of young children.

Design  Randomized controlled trial.

Setting  Urban public hospital pediatric emergency department.

Participants  Parents and caregivers (N = 245) of children aged 30 days to 8 years who were prescribed liquid medications (daily dose or “as needed”).

Intervention  Medication counseling using plain language, pictogram-based medication instruction sheets. Control subjects received standard medication counseling.

Outcome Measures  Medication knowledge and practice, dosing accuracy, and adherence.

Results  Of 245 randomized caregivers, 227 underwent follow-up assessments (intervention group, 113; control group, 114). Of these, 99 were prescribed a daily dose medication, and 158 were prescribed medication taken as needed. Intervention caregivers had fewer errors in observed dosing accuracy (>20% deviation from prescribed dose) compared with caregivers who received routine counseling (daily dose: 5.4% vs 47.8%; absolute risk reduction [ARR], 42.4% [95% confidence interval, 24.0%-57.0%]; number needed to treat [NNT], 2 [2-4]; as needed: 15.6% vs 40.0%; ARR, 24.4% (8.7%-38.8%); NNT, 4 [3-12]). Of intervention caregivers, 9.3% were nonadherent (ie, did not give within 20% of the total prescribed doses) compared with 38.0% of controls (ARR, 28.7% [11.4%-43.7%]; NNT, 3 [2-9]). Improvements were also seen for knowledge of appropriate preparation for both medication types, as well as knowledge of frequency for those prescribed daily dose medications.

Conclusion  A plain language, pictogram-based intervention used as part of medication counseling resulted in decreased medication dosing errors and improved adherence among multiethnic, low socioeconomic status caregivers whose children were treated at an urban pediatric emergency department.

Trial Registration  clinicaltrials.gov Identifier: NCT00537433

Figures in this Article

Evidence suggests that parents and caregivers make frequent errors when administering medications to children. These errors, which include inaccurate dosing as well as nonadherence to medication regimens, place children at risk for morbidity and mortality.15 Misdosing is prevalent, with 50% or more of pediatric caregivers either measuring an incorrect dose or reporting having given a dose of liquid medication outside the recommended range.611 Of further concern are reports of a poor overall adherence rate of 50% for pediatric medications,3,12,13 which has implications for treatment failure and drug resistance.2,12,1416

Medication-specific issues, as well as factors related to health care provider and caregiver characteristics, contribute to medication administration errors in children. Medication-specific issues in children are frequently related to reliance on liquid formulations,6,8,1719 including availability of medications in different concentrations,11,20 palatability,8,12 and wide variation in the accuracy of dosing instruments.8,9,18,19,21 Health care provider communication issues contribute to confusion about medication administration, particularly when instructions are complex12,14,22,23 and when directions for liquid medications are given using different units of measure, including milliliters, teaspoons, or tablespoons.19 Caregiver-specific issues include language barriers, literacy level, cultural perceptions, and cost.3,12,23,24 These caregiver-related issues disproportionately affect low socioeconomic status (SES) caregivers.

Few studies have examined strategies for decreasing medication administration errors among pediatric patients.6 Pictograms represent a promising approach in which simple diagrams are used to improve understanding of concepts.2528 Pictorial-enhanced written materials have been shown to improve comprehension of and adherence to medical directions,25,2935 particularly for patients with low literacy.3437 However, existing studies of pictogram-enhanced medication instructions have assessed adult rather than pediatric medication regimens.29,30 Two additional strategies for which there is empirical support are “teachback,” in which patients or caregivers are asked to repeat back instructions or physically demonstrate steps involved in a task,38,39 and provision of oral dosing syringes.8,18

We developed a pictogram-based intervention to decrease dosing errors and improve adherence. This was created as part of New York University/Bellevue Hospital Center's Health Education and Literacy for Parents (HELP) project, which helps low literacy, limited-English–proficient parents of young children understand health information. The intervention, HELPix, or HELP pictograms, uses plain language, pictogram-based medication- and patient-specific instruction sheets to help facilitate counseling regarding medication dose and adherence, as well as correct usage of a standardized dosing instrument (http://HELPix.med.nyu.edu). In this study, we sought to assess whether this intervention would reduce medication dosing errors and improve adherence in a pediatric emergency department (ED) serving at-risk families.

PARTICIPANTS, RECRUITMENT, AND RANDOMIZATION

This study was a randomized controlled trial to test the efficacy of the HELPix intervention. Institutional review board approval was obtained from New York University School of Medicine and Bellevue Hospital Center. Parents and caregivers provided written, informed consent before participating in the study.

Subjects were enrolled from the pediatric ED at Bellevue Hospital Center, an urban public hospital, between July 12 and December 7, 2006. The Bellevue pediatric ED serves primarily at-risk families with low education and low SES and registers approximately 20 000 visits per year. During daytime and evening hours when study enrollment took place, research assistants consecutively assessed parents and caregivers to determine eligibility.

Inclusion criteria were having a child aged 30 days through 8 years who was prescribed a liquid medication (daily dose [short course (≤14 days)] or as-needed medication). Exclusion criteria were caregiver accompanying the child to the visit not being primarily responsible for administering medication or not fluent in English or Spanish; child requiring immediate medical attention; child typically taking medications in tablet form; or child having a psychiatric or child-protection–related visit.

Enrolled caregivers were randomized to receive the pictogram-based intervention or standard care (control group). Randomization was performed using sealed envelopes in blocks of 50, 25 each for the intervention and control groups. Trained research assistants delivered the intervention to caregivers at the time of ED discharge.

INTERVENTION

Plain language, pictogram-based medication instruction sheets, in English and Spanish, were the core of HELPix (eFigure 1 and eFigure 2). The instruction sheets used pictograms to convey information about medication name, indication, dose, dose frequency, length of treatment, preparation, and storage. The sheets also included a medication log for parents to keep track of medication administration. The 2-page medication information sheets were generated using software developed for this project and were based on data from standard pharmaceutical references.40,41 We developed separate templates for daily dose and as-needed medications, reflecting differences in the way these medications are administered.4244

Research assistants trained and supervised by one of us (H.S.Y.) used the instruction sheets to facilitate medication counseling, including teaching about dosage and adherence. During counseling, research staff referenced the sheets as they demonstrated dosing with a standardized instrument; parents then demonstrated to research staff how they planned to administer medication, a process referred to as “teachback.” For medications with which a standardized dosing instrument was not included at dispensing, an oral dosing syringe was provided for the caregiver to use at home. After counseling, the caregiver was given the instruction sheet to take home and instructed to use it to facilitate and guide medication administration. The intervention, which included counseling and teachback, took 1½ to 3 minutes to complete for each caregiver, depending on the complexity of the regimen.

STANDARD MEDICATION COUNSELING

Families in the control group received standard care, including routine counseling regarding prescribed medications and postvisit counseling by the pediatric nursing staff. Dosing instruments were given at the discretion of the physician or nurse, but this was not part of routine practice. Medications were typically dispensed at a pharmacy outside the institution; medication counseling was provided by the pharmacist as mandated by state law.45

ASSESSMENTS

Assessments were performed at baseline before the intervention as well as at follow-up. Interviews were conducted by research assistants in English or Spanish based on caregiver preference. A modest incentive was provided for families to encourage participation ($5 for intake, $20 for follow-up).

Baseline

We assessed sociodemographic characteristics, the child's medical history, and caregiver health literacy level.

Sociodemographic data, including the child's age and sex as well as caregiver age, marital status, country of origin, ethnicity, language, educational level, occupation, and relationship to the child, were obtained via a structured questionnaire. Family Hollingshead Four-Factor SES was based on education and occupation.46

The child's medical history was assessed, including history of chronic medical problems and whether the child took medication regularly.

Caregiver health literacy level was assessed with the Test of Functional Health Literacy in Adults (TOFHLA).47 Functional health literacy was categorized as inadequate, marginal, or adequate, as designated in the TOFHLA manual.48 The test has been shown to correlate with the Wide Range Achievement Test as well as the Rapid Estimate of Adult Literacy in Medicine47 and has been used in multiple studies to assess health literacy.16,49,50 The TOFHLA is validated in English and Spanish.51 In 8 cases, time constraints led us to administer a short version of the TOFHLA,52 which yielded the same set of categories.

Follow-up

Follow-up assessments took place either by telephone and/or in person, planned at 3 to 5 days after the ED visit for as-needed medications and within 1 day of the projected end date for daily dose medications. These included assessments of knowledge and behavior, dosing accuracy, and adherence (for daily dose medications only). Blinding was not maintained during follow-up assessments because caregivers who received the pictogram-based instruction sheets were aware of their randomization status and revealed their status during assessments. In addition, the same research assistants were frequently involved in both intake and follow-up assessments.

Knowledge and Related Medication Practices

Caregivers were asked about the name and indication of each prescribed medication, as well as dose frequency, preparation, storage, and dosing instrument use.

Caregivers were considered to have accurate knowledge of dose frequency if they reported a number of prescribed doses per day that exactly matched the number of doses prescribed by the physician. Those who gave a response that was more or less than the number of doses prescribed were considered to be incorrect.

Related medication practices assessed included appropriate method of preparation and mode of storage. Responses were dichotomized as correct or incorrect on the basis of medication-specific information obtained from standard pharmaceutical references.40,41 Caregivers were also asked to report which dosing instrument they used at home.

Dosing Accuracy

Dosing accuracy was assessed by caregiver interview and through direct observation. For both self-reported and observed dosing accuracy, the primary criterion used was whether the amount was within 20% of the prescribed dose. We chose this criterion on the basis of other studies of medication dosing accuracy.9,53 We also analyzed the data using a criterion of 40% to determine the effect of dosing errors of larger magnitude.

To assess dosing accuracy via direct observation, caregivers underwent a structured observation at follow-up. Caregivers were asked to bring in any materials they used at home, including the medication bottle, dosing instrument, and instructions, and were asked to measure the dose as they would at home using a standardized medication bottle and their own dosing instrument. Those who did not bring in their dosing instrument were asked to select from the dosing instruments provided by research staff, which included a kitchen teaspoon, kitchen tablespoon, dosing spoon, measuring spoon, dosing cup, 5-mL dropper, acetaminophen infant dropper, ibuprofen-specific dropper, and 1-, 3-, 5-, 10-, and 12-mL syringes. Interrater reliability, measured by having 2 raters (including H.S.Y.) assess dosing accuracy using the 20% criterion for a subsample of 75 parents, was high (κ > 0.9).

Adherence

We estimated the total number of doses given by the caregiver from the time and date of first and last dose, reported frequency of doses, and number of doses reported missing. We then calculated the percentage of prescribed doses given (total number of doses given divided by total number of doses prescribed). We considered caregivers to be nonadherent if they deviated from the number of doses prescribed by more than 20%.5457 We also compared the randomization groups for nonadherence using a criterion of 40%, as was done for dosing accuracy.

We also assessed nonadherence according to whether caregivers completed their medication course,58 using the reported start time and date to calculate the appropriate final date of the treatment course. We compared nonadherence between the 2 groups based on 2 different criteria: not giving the last dose on the expected last date and not giving the last dose within 1 day of the expected last date.

STATISTICAL ANALYSES

The baseline characteristics of the intervention and control families were compared using t tests and χ2 tests or Fisher exact tests, as appropriate. Similar analyses were performed to compare families who did and did not undergo follow-up assessments.

Statistical analyses to assess differences in medication knowledge and related medication practices, as well as dosing accuracy, were performed for the daily dose and as-needed medication groups separately because of differences in administration,4244 which then led to the creation of separate medication instruction sheet templates. For the limited number of patients who received more than 1 daily dose or as-needed medication (7 patients), only the first medication documented in the visit record was included in the analysis. For patients who received a medication prescription involving tapered dosing over time, the most recent dose was used for the analysis.

Outcomes were compared using Fisher exact tests for categorical variables and independent samples t tests for continuous variables. Absolute risk reduction, relative risk reduction, and number needed to treat, along with 95% confidence intervals, were calculated for each outcome of interest.

Because child's sex was close to being statistically significant between randomized groups (P = .053), we performed multivariate analyses adjusting for sex for each outcome of interest. Adjusting for sex did not change outcomes; therefore, we present unadjusted analyses only.

Data were analyzed using SPSS statistical software, version 14.0 (SPSS Inc, Chicago, Illinois). A 2-tailed P value <.05 was considered to be statistically significant. Sample size estimates were based on the outcome of dosing accuracy. A conservative estimate of the baseline rate of caregiver liquid medication dosing error is 40% to 50%.611 We calculated a sample size of approximately 245 parents enrolled in the study (with a 25% anticipated loss to follow-up) to achieve 80% power (2-sided α = .05) to detect a reduction in dosing error rate of 20% to 30% in the group receiving the pictogram-based intervention compared with the group receiving standard counseling.

From July 12 through December 7, 2006, 3309 children who met inclusion criteria visited the ED; 1290 pediatric visits involving 1100 caregivers occurred during the daytime and early evening hours when research assistants were present (Figure 1). Of 1100 caregivers, 815 (74.1%) were assessed for additional inclusion criteria. Although research assistants endeavored to assess consecutive families, 285 caregivers (25.9%) were not assessed because their children were immediately called to be seen by the physician or because of competing demands as research assistants enrolled other families. Based on 1 or more of the study criteria, 522 caregivers (67.7%) were determined to be ineligible. There was no statistically significant difference between families who were and were not enrolled with respect to child's age and sex.

Place holder to copy figure label and caption
Figure 1.

Study enrollment.

Graphic Jump Location

Of 251 caregivers enrolled in the study, 6 left before randomization (0.2%). Of 245 caregivers randomized, 124 (50.6%) were allocated to receive the pictogram-based medication instruction sheets, whereas 121 (49.4%) were allocated to the control group. This included 107 families (43.7%) prescribed daily dose medications (intervention, 52; control, 55) and 171 families (69.8%) prescribed as-needed medications (intervention, 87; control, 84). (Some families received both as-needed and daily dose medications.) Randomized families were compared for baseline variables (Table 1). No statistically significant differences were seen, although a nonsignificant trend was seen for sex (P = .053). In addition, no statistically significant differences were seen in the type of medication prescribed to children in the intervention and control groups (Table 2).

Table Graphic Jump LocationTable 1. Baseline Characteristics by Randomization Groupa
Table Graphic Jump LocationTable 2. Prescribed Medication Characteristics by Randomization Groupa

Of 245 randomized families, 227 (92.7%) underwent follow-up assessments by telephone, in person, or both, and rates were similar for intervention and control families (91.1% vs 94.2%, respectively; P = .50). Follow-up assessments were conducted by telephone only for 46 families (20.3%), in person only for 62 (27.3%), and by telephone and in person for 119 (52.4%). Because assessment of observed dosing accuracy required in-person follow-up, only 181 of 245 randomized families (73.9%) were assessed for that measure. Mean (SD) follow-up time for observed dosing accuracy was 12.1 (9.8) days. There were no differences in caregiver characteristics for those who did and did not return for the observed dosing assessment.

All intervention caregivers received a standardized dosing instrument, from the ED research assistant (92.7%) and/or the pharmacy (33.3%), as a standard component of medication packaging. In the control group, 55.3% of caregivers received dosing instruments, from the ED staff (23.0%) and/or the pharmacy (38.4%).

MEDICATION KNOWLEDGE AND RELATED PRACTICES

As shown in Table 3, intervention caregivers who were prescribed daily dose medications were less likely to make errors in knowledge of dose frequency compared with control caregivers (0% vs 15.1%; P = .007). However, there was no difference in knowledge of dose frequency for as-needed medications. Intervention caregivers were also less likely than control caregivers to report incorrect medication preparation, related to shaking the medication before administration, for both daily dose (10.9% vs 28.3%; P = .04) and as-needed (21.5% vs 43.0%; P = .006) medications. No differences were seen in knowledge of medication name, indication, or storage. With respect to dosing instrument, caregivers in the intervention group were significantly more likely to report the use of a standardized dosing instrument compared with caregivers in the control group for both daily dose and as-needed medications (daily dose: 93.5% vs 71.7%, P = .008; as needed: 93.7% vs 74.7%; P = .002).

Table Graphic Jump LocationTable 3. Medication Knowledge and Related Practices: Error Ratesa
DOSING ACCURACY

Figure 2A and B show frequencies in observed dosing accuracy by randomization group for daily dose and as-needed medications, respectively.

Place holder to copy figure label and caption
Figure

2. Observed dosing accuracy among caregivers whose children were prescribed daily dose (A) and as-needed (B) medications. Among those who were prescribed as-needed medications (B), 3 individuals who received standard medication counseling were excluded owing to a mismatch in the concentration of acetaminophen prescribed vs that given (infant drops vs children’s concentration).

Graphic Jump Location

As seen in Table 4, caregiver accuracy was higher among intervention families prescribed daily dose and as-needed medications, regardless of whether the cutoff point for a dosing error was set at 20% or 40% deviation from the prescribed dose. In the structured observation, for example, 5.4% of intervention caregivers whose children had been prescribed daily dose medications gave inaccurate doses at the 20% cutoff point, compared with 47.8% of control caregivers.

Table Graphic Jump LocationTable 4. Medication Dosing Accuracy: Error Ratesa

Because intervention families were more likely to use a standardized dosing instrument, we performed secondary analyses of observed dosing accuracy in which we included only those caregivers who used a standardized dosing instrument. Using the 20% cutoff point, we found that errors in observed accuracy remained significantly different in the intervention and control groups for both daily dose and as-needed medications (daily dose: 5.0% vs 35.3%; P = .003; as-needed: 16.4% vs 36.2%; P = .02).

ADHERENCE

Nonadherence was lower in the intervention group for both categories of adherence (percentage of total prescribed doses given and date of last dose given) as well as for each specific criterion (eg, 20% vs 40% of total doses) (Table 5). For example, 9.3% of intervention caregivers were found to be nonadherent (child not given within 20% of total prescribed doses) compared with 38.0% of control caregivers.

Table Graphic Jump LocationTable 5. Medication Nonadherence Ratesa

Although vigilance in the calculation of weight-based medication doses is considered to be a routine part of pediatric medicine, there has been limited focus on prevention of medication administration errors made by parents and caregivers of young children. In a randomized controlled trial, we found that a pictogram-based intervention significantly improved caregiver accuracy and adherence in administering liquid medications. Other effects were also seen, including enhanced knowledge of dosing frequency for daily dose medications and improved medication preparation practices. The low resource requirements for this intervention, along with a large reduction in risk and a small number needed to treat, support its potential utility in clinical practice.

Two aspects related to research methods specifically support the validity of our results. First, we used different types of assessments, including parent report and observation, each of which yielded consistent findings. Second, we used multiple cutoff points as criteria for dosing accuracy and nonadherence, which also yielded consistent results. We note that there are no standard criteria for acceptable accuracy of dosing or nonadherence, with examples in the literature of 0.2 mL up to 20% deviation from the recommended or prescribed doses8,9 and 0% to 30% deviation from the prescribed number of doses for nonadherence.3,14,16,54,57,59,60

Our findings are consistent with existing data regarding the use of pictorial illustrations and medication instructions.25,29,30,33 Pictorial illustrations have been found to reinforce and draw attention to written information2630,6163 and are particularly helpful for patients with low literacy.3437 Few studies have assessed pictorial illustrations and medication administration for pediatric medications, although 1 study found improved maternal knowledge of oral rehydration therapy when pictorial-enhanced materials were used.64

There are limitations to our study. We were unable to maintain blinding, in part owing to staff limitations but also because families frequently revealed their randomization group during the follow-up assessments, either verbally or when asked to show research assistants what written materials they had used to help them administer the medication. However, surveys used for assessments were highly structured and not likely to be subjective, and interrater reliability was high for observed dosing accuracy. In addition, although the overall rate of follow-up was high (more than 90%), the rate of in-person follow-up was lower. Nonetheless, results of observed dosing accuracy were similar to those of self-reported dosing accuracy. We were also unable to determine the relative effect of each of the components of the intervention: the pictogram-based sheets, teachback, and provision of the standardized dosing instrument. Although secondary analyses of caregivers in both groups who used standardized dosing instruments suggest that the pictogram-based sheets had an effect greater than that of the dosing instrument alone, additional randomized studies would be needed to fully address this issue. Finally, our results may not be generalizable because this study was performed in an urban pediatric ED that serves a primarily low SES, immigrant, Hispanic population, and only English- and Spanish-speaking caregivers were enrolled. The patients in this sample were at increased risk of medication error, and we do not know whether risk reductions would have been as large in a lower-risk group.

We do not yet know whether this intervention would be more or less effective with different subpopulations of parents, based on risk factors related to medication errors. Future analyses will be performed to compare the efficacy of the intervention by education, health literacy, and SES. In addition, we plan to further assess the intervention with medications used long term as well as with other medication formulations, such as tablets and creams.

In summary, we found that use of a plain language, pictogram-based intervention, which included teachback and provision of standardized dosing instruments, resulted in decreased medication dosing errors and improved medication adherence among caregivers whose children were prescribed liquid medications. This pictogram-based intervention represents a promising innovation with the potential to improve pediatric health and promote patient safety.

Correspondence: H. Shonna Yin, MD, MS, Department of Pediatrics, New York University School of Medicine, 550 First Ave, NBV 8S4-11, New York, NY 10016 (yinh02@med.nyu.edu).

Submitted for Publication: January 31, 2008.

Author Contributions: All the authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Yin, Dreyer, van Schaick, and Mendelsohn. Acquisition of data: Yin and Dinglas. Analysis and interpretation of data: Yin, Dreyer, van Schaick, Foltin, and Mendelsohn. Drafting of the manuscript: Yin and Mendelsohn. Critical revision of the manuscript for important intellectual content: Yin, Dreyer, van Schaick, Foltin, Dinglas, and Mendelsohn. Statistical analysis: Yin, Dreyer, and Mendelsohn. Obtained funding: Yin, Dreyer, and Mendelsohn. Administrative, technical, or material support: Yin, van Schaick, and Dinglas. Study supervision: Yin, Dreyer, Foltin, and Mendelsohn.

Financial Disclosure: None reported.

Funding/Support: This study was supported by grant T01 CD000146 from the Centers for Disease Control and Prevention, the Pfizer Fellowship in Health Literacy/Clear Health Communication, and the New York University Department of Pediatrics Joseph Dancis Research Fund.

Disclaimer: The contents of this study are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention.

Previous Presentations: This study was presented at the 2007 Pediatric Academic Societies' Annual Meeting; May 7, 2007; Toronto, Ontario, Canada, and at the ACP/IOM (American College of Physicians/Institute of Medicine) Sixth Annual National Health Communication Conference; November 28, 2007; Washington, DC.

Additional Contributions: Nancy Linn, MFA, helped design the graphics for the medication instruction sheets. Jill Linnell, MPH, and Claudia Aristy, BA, assisted with instruction sheet development. Liang Yin, MS, developed the computer application. Stephanie DeFiores, MS, Meyling Oei, BA, and Neha Sathe, BA, were senior research assistants. We acknowledge Marc Gourevitch, MD, MPH, and Mark Schwartz, MD, who direct the Centers for Disease Control and Prevention/New York University Medicine and Public Health Research Fellowship Program, and Isabel Bazan, BA, Amy Chu, BS, Carolyn Cutler, BA, Michelle Diaz, BA, Leydi Espinal, BA, Giselle Jose, BA, Lindsay Katona, BA, Eric Levy, BA, Katherine Milligan, BA, Heidi Mock, BA, Susanna Silverman, BA, Margaret Wolff, BA, Julie Wytock, BS, and the staff of Bellevue Hospital's pediatric emergency department for their assistance with this study.

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PubMed
Delp  CJones  J Communicating information to patients: the use of cartoon illustrations to improve comprehension of instructions. Acad Emerg Med 1996;3 (3) 264- 270
PubMed
Austin  PEMatlack  RDunn  KAKesler  CBrown  CK Discharge instructions: do illustrations help our patients understand them? Ann Emerg Med 1995;25 (3) 317- 320
PubMed
Hanson  EC Evaluating cognitive services for non-literate and visually impaired patients in community pharmacy rotation sites Am J Pharm Educ 1995;59 (1) 48- 55
Michielutte  RBahnson  JDignan  MBSchroeder  EM The use of illustrations and narrative text style to improve readability of a health education brochure. J Cancer Educ 1992;7 (3) 251- 260
PubMed
Schillinger  DPiette  JGrumbach  K  et al.  Closing the loop: physician communication with diabetic patients who have low health literacy. Arch Intern Med 2003;163 (1) 83- 90
PubMed
Mayeaux  EJ  JrMurphy  PWArnold  CDavis  TCJackson  RHSentell  T Improving patient education for patients with low literacy skills. Am Fam Physician 1996;53 (1) 205- 211
PubMed
 Physicians' Desk Reference. 60th ed. Montvale, NJ Thomson2006;
Taketomo  CHodding  JKraus  D Pediatric Dosage Handbook. 13th ed. Hudson, OH Lexi-Comp2006;
Miaskowski  CDodd  MWest  C  et al.  Lack of adherence with the analgesic regimen: a significant barrier to effective cancer pain management. J Clin Oncol 2001;19 (23) 4275- 4279
PubMed
Gunn  VLTaha  SHLiebelt  ELSerwint  JR Toxicity of over-the-counter cough and cold medications. Pediatrics 2001;108 (3) e52
PubMed10.1542/peds.108.3.e52
Heubi  JEBarbacci  MBZimmerman  HJ Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. J Pediatr 1998;132 (1) 22- 27
PubMed
New York State Department of Education, Office of the Professions,Commissioner's Regulations, Part 63, Pharmacy, §63.6 b 8 (i) a and b. http://www.op.nysed.gov/part63.htm. Accessed June 6, 2007
Hollingshead  A Four Factor Index of Social Status.  New Haven, CT Yale University1975;
Parker  RMBaker  DWWilliams  MVNurss  JR The test of functional health literacy in adults: a new instrument for measuring patients' literacy skills. J Gen Intern Med 1995;10 (10) 537- 541
PubMed
Nurss  JParker  RBaker  D TOFHLA: Test of Functional Health Literacy in Adults.  Snow Camp, NC Peppercorn Books & Press1995;
Gazmararian  JBaker  DParker  RBlazer  DG A multivariate analysis of factors associated with depression: evaluating the role of health literacy as a potential contributor. Arch Intern Med 2000;160 (21) 3307- 3314
PubMed
Schillinger  DGrumbach  KPiette  J Association of health literacy with diabetes outcomes. JAMA 2002;288 (4) 475- 482
PubMed
Schwartzberg  JGVan Geest  JBWang  CC Understanding Health Literacy: Implications for Medicine and Public Health.  Chicago, IL AMA Press2005;
Aguirre  ACEbrahim  NShea  JA Performance of the English and Spanish S-TOFHLA among publicly insured Medicaid and Medicare patients. Patient Educ Couns 2005;56 (3) 332- 339
PubMed
Kozer  EScolnik  DMacpherson  A  et al.  Variables associated with medication errors in pediatric emergency medicine. Pediatrics 2002;110 (4) 737- 742
PubMed
Katon  WCantrell  CRSokol  MCChiao  EGdovin  JM Impact of antidepressant drug adherence on comorbid medication use and resource utilization. Arch Intern Med 2005;165 (21) 2497- 2503
PubMed
Lau  DTNau  D Oral antihyperglycemic medication nonadherence and subsequent hospitalization among individuals with type 2 diabetes. Diabetes Care 2004;27 (9) 2149- 2153
PubMed
Wei  LWang  JThompson  PWong  SStruthers  AMacDonald  T Adherence to statin treatment and readmission of patients after myocardial infarction: a six-year follow-up study. Heart 2002;88 (3) 229- 233
PubMed
Edwards  MPathy  MS Drug counselling in the elderly and predicting compliance. Practitioner 1984;228 (1389) 291- 300
PubMed
Dawson  ANewell  R The extent of parental compliance with timing of administration of their children's antibiotics. J Adv Nurs 1994;20 (3) 483- 490
PubMed
Paasche-Orlow  MKCheng  DMPalepu  AMeli  SFaber  VSamet  JH Health literacy, antiretroviral adherence, and HIV-RNA suppression: a longitudinal perspective. J Gen Intern Med 2006;21 (8) 835- 840
PubMed
Beck  DEFennell  RSYost  RLRobinson  JDGeary  DRichards  GA Evaluation of an educational program on compliance with medication regimens in pediatric patients with renal transplants. J Pediatr 1980;96 (6) 1094- 1097
PubMed
Bernardini  CAmbrogi  VPerioli  LCTiralti  MCFardella  G Comprehensibility of the package leaflets of all medicinal products for human use: a questionnaire survey about the use of symbols and pictograms. Pharmacol Res 2000;41 (6) 679- 688
PubMed
Houts  PSBachrach  RWitmer  JTTringali  CABucher  JALocalio  RA Using pictographs to enhance recall of spoken medical instructions. Patient Educ Couns 1998;35 (2) 83- 88
PubMed
Filippatou  DPumfrey  PD Pictures, titles, reading accuracy and reading comprehension: a research review (1973-95). Educ Res 1996;38 (3) 259- 29110.1080/0013188960380302
Patel  VLEisemon  TOArocha  JF Comprehending instructions for using pharmaceutical products in rural Kenya. Instr Sci 1990;1971- 8410.1007/BF00377986

Figures

Place holder to copy figure label and caption
Figure 1.

Study enrollment.

Graphic Jump Location
Place holder to copy figure label and caption
Figure

2. Observed dosing accuracy among caregivers whose children were prescribed daily dose (A) and as-needed (B) medications. Among those who were prescribed as-needed medications (B), 3 individuals who received standard medication counseling were excluded owing to a mismatch in the concentration of acetaminophen prescribed vs that given (infant drops vs children’s concentration).

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Baseline Characteristics by Randomization Groupa
Table Graphic Jump LocationTable 2. Prescribed Medication Characteristics by Randomization Groupa
Table Graphic Jump LocationTable 3. Medication Knowledge and Related Practices: Error Ratesa
Table Graphic Jump LocationTable 4. Medication Dosing Accuracy: Error Ratesa
Table Graphic Jump LocationTable 5. Medication Nonadherence Ratesa

References

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Dowse  REhlers  M Pictograms in pharmacy. Int J Pharm Pract 1998;6109- 118
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Houts  PSWitmer  JTEgeth  HELoscalzo  MJZabora  JR Using pictographs to enhance recall of spoken medical instructions II. Patient Educ Couns 2001;43 (3) 231- 242
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Morrow  DGHier  CMMenard  WELeirer  VO Icons improve older and younger adults' comprehension of medication information. J Gerontol B Psychol Sci Soc Sci 1998;53 (4) P240- P254
PubMed
Ngoh  LNShepherd  MD Design, development, and evaluation of visual aids for communicating prescription drug instructions to nonliterate patients in rural Cameroon. Patient Educ Couns 1997;30 (3) 257- 270
PubMed
Delp  CJones  J Communicating information to patients: the use of cartoon illustrations to improve comprehension of instructions. Acad Emerg Med 1996;3 (3) 264- 270
PubMed
Austin  PEMatlack  RDunn  KAKesler  CBrown  CK Discharge instructions: do illustrations help our patients understand them? Ann Emerg Med 1995;25 (3) 317- 320
PubMed
Hanson  EC Evaluating cognitive services for non-literate and visually impaired patients in community pharmacy rotation sites Am J Pharm Educ 1995;59 (1) 48- 55
Michielutte  RBahnson  JDignan  MBSchroeder  EM The use of illustrations and narrative text style to improve readability of a health education brochure. J Cancer Educ 1992;7 (3) 251- 260
PubMed
Schillinger  DPiette  JGrumbach  K  et al.  Closing the loop: physician communication with diabetic patients who have low health literacy. Arch Intern Med 2003;163 (1) 83- 90
PubMed
Mayeaux  EJ  JrMurphy  PWArnold  CDavis  TCJackson  RHSentell  T Improving patient education for patients with low literacy skills. Am Fam Physician 1996;53 (1) 205- 211
PubMed
 Physicians' Desk Reference. 60th ed. Montvale, NJ Thomson2006;
Taketomo  CHodding  JKraus  D Pediatric Dosage Handbook. 13th ed. Hudson, OH Lexi-Comp2006;
Miaskowski  CDodd  MWest  C  et al.  Lack of adherence with the analgesic regimen: a significant barrier to effective cancer pain management. J Clin Oncol 2001;19 (23) 4275- 4279
PubMed
Gunn  VLTaha  SHLiebelt  ELSerwint  JR Toxicity of over-the-counter cough and cold medications. Pediatrics 2001;108 (3) e52
PubMed10.1542/peds.108.3.e52
Heubi  JEBarbacci  MBZimmerman  HJ Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. J Pediatr 1998;132 (1) 22- 27
PubMed
New York State Department of Education, Office of the Professions,Commissioner's Regulations, Part 63, Pharmacy, §63.6 b 8 (i) a and b. http://www.op.nysed.gov/part63.htm. Accessed June 6, 2007
Hollingshead  A Four Factor Index of Social Status.  New Haven, CT Yale University1975;
Parker  RMBaker  DWWilliams  MVNurss  JR The test of functional health literacy in adults: a new instrument for measuring patients' literacy skills. J Gen Intern Med 1995;10 (10) 537- 541
PubMed
Nurss  JParker  RBaker  D TOFHLA: Test of Functional Health Literacy in Adults.  Snow Camp, NC Peppercorn Books & Press1995;
Gazmararian  JBaker  DParker  RBlazer  DG A multivariate analysis of factors associated with depression: evaluating the role of health literacy as a potential contributor. Arch Intern Med 2000;160 (21) 3307- 3314
PubMed
Schillinger  DGrumbach  KPiette  J Association of health literacy with diabetes outcomes. JAMA 2002;288 (4) 475- 482
PubMed
Schwartzberg  JGVan Geest  JBWang  CC Understanding Health Literacy: Implications for Medicine and Public Health.  Chicago, IL AMA Press2005;
Aguirre  ACEbrahim  NShea  JA Performance of the English and Spanish S-TOFHLA among publicly insured Medicaid and Medicare patients. Patient Educ Couns 2005;56 (3) 332- 339
PubMed
Kozer  EScolnik  DMacpherson  A  et al.  Variables associated with medication errors in pediatric emergency medicine. Pediatrics 2002;110 (4) 737- 742
PubMed
Katon  WCantrell  CRSokol  MCChiao  EGdovin  JM Impact of antidepressant drug adherence on comorbid medication use and resource utilization. Arch Intern Med 2005;165 (21) 2497- 2503
PubMed
Lau  DTNau  D Oral antihyperglycemic medication nonadherence and subsequent hospitalization among individuals with type 2 diabetes. Diabetes Care 2004;27 (9) 2149- 2153
PubMed
Wei  LWang  JThompson  PWong  SStruthers  AMacDonald  T Adherence to statin treatment and readmission of patients after myocardial infarction: a six-year follow-up study. Heart 2002;88 (3) 229- 233
PubMed
Edwards  MPathy  MS Drug counselling in the elderly and predicting compliance. Practitioner 1984;228 (1389) 291- 300
PubMed
Dawson  ANewell  R The extent of parental compliance with timing of administration of their children's antibiotics. J Adv Nurs 1994;20 (3) 483- 490
PubMed
Paasche-Orlow  MKCheng  DMPalepu  AMeli  SFaber  VSamet  JH Health literacy, antiretroviral adherence, and HIV-RNA suppression: a longitudinal perspective. J Gen Intern Med 2006;21 (8) 835- 840
PubMed
Beck  DEFennell  RSYost  RLRobinson  JDGeary  DRichards  GA Evaluation of an educational program on compliance with medication regimens in pediatric patients with renal transplants. J Pediatr 1980;96 (6) 1094- 1097
PubMed
Bernardini  CAmbrogi  VPerioli  LCTiralti  MCFardella  G Comprehensibility of the package leaflets of all medicinal products for human use: a questionnaire survey about the use of symbols and pictograms. Pharmacol Res 2000;41 (6) 679- 688
PubMed
Houts  PSBachrach  RWitmer  JTTringali  CABucher  JALocalio  RA Using pictographs to enhance recall of spoken medical instructions. Patient Educ Couns 1998;35 (2) 83- 88
PubMed
Filippatou  DPumfrey  PD Pictures, titles, reading accuracy and reading comprehension: a research review (1973-95). Educ Res 1996;38 (3) 259- 29110.1080/0013188960380302
Patel  VLEisemon  TOArocha  JF Comprehending instructions for using pharmaceutical products in rural Kenya. Instr Sci 1990;1971- 8410.1007/BF00377986

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