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The Pediatric Forum |

Hypermagnesemia With Lethargy and Hypotonia Due to Administration of Magnesium Hydroxide to a 4-Week-Old Infant

Janice E. Sullivan, MD; Brian W. Berman, MD
Arch Pediatr Adolesc Med. 2000;154(12):1272-1274. doi:.
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The administration of over-the-counter medications to infants and small children is widespread, occasionally leading to life-threatening toxic effects. Classic examples are acetaminophen and aspirin. We present the case of a 4½-week-old male infant who had a 24-hour history of decreased responsiveness ultimately shown to be due to hypermagnesemia.

Van Hook  JW Hypermagnesemia. Crit Care Clin. 1991;7215- 223
Mofenson  HCCarraccio  TR Magnesium intoxication in a neonate from oral magnesium hydroxide laxative. J Toxicol Clin Toxicol. 1991;29215- 222
Link to Article[[XSLOpenURL/10.3109/15563659109038614]]
Caddell  JL Magnesium in perinatal care and infant health. Magnes Trace Elem. 1991;10229- 250
Baumgartner  TG Magnesium in Clinical Guide to Parenteral Micronutrition.  Deerfield, Ill Fujisawa USA Inc1991;
Brady  JWilliams  H Magnesium intoxication in a premature infant. Pediatrics. 1967;40100- 103
Teng  RLiu  HYau  K Neonatal hypermagnesemia: report of one case. Acta Paed Sin. 1989;30333- 335
Lipsitz  PJEnglish  IC Hypermagnesemia in the newborn infant. Pediatrics. 1967;40856- 862
Humphrey  MKennon  SPramanik  AK Hypermagnesemia from antacid administration in a newborn infant. J Pediatr. 1981;98313- 314
Link to Article[[XSLOpenURL/10.1016/S0022-3476(81)80669-5]]
Brand  JMGreer  FR Hypermagnesemia and intestinal perforation following antacid administration in a premature infant. Pediatrics. 1990;85121- 124
Alison  LHBulugahapitiya  D Laxative induced magnesium poisoning in a 6 week old infant. BMJ. 1990;300125
Link to Article[[XSLOpenURL/10.1136/bmj.300.6717.125-a]]
Smilkstein  MJSmolinske  SCKulig  KWRumack  BH Severe hypermagnesemia due to multiple-dose cathartic therapy. West J Med. 1988;148208- 211
Fassler  CARodriguez  MBadesch  DBStone  WJMarini  JJ Magnesium toxicity as a cause of hypotension and hypoventilation. Arch Intern Med. 1985;1451604- 1606
Link to Article[[XSLOpenURL/10.1001/archinte.1985.00360090068012]]
Jones  JHeiselman  DDougherty  JEddy  A Cathartic-induced magnesium toxicity during overdose management. Ann Emerg Med. 1986;151214- 1218
Link to Article[[XSLOpenURL/10.1016/S0196-0644(86)80870-8]]
Gendreau  M Gastric lavage. Clin Tox Rev. 1997;19

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