The Pediatric Forum |

Variables Influencing Penicillin Treatment Outcome

Michael E. Pichichero, MD; William Hoeger, MD; Steven M. Marsocci, MD; A. Marie Lynd Murphy, MD; Anne B. Francis, MD; Vladimir Dragalin, PhD
Arch Pediatr Adolesc Med. 2000;154(1):91. doi:.
Text Size: A A A
Published online


In reply

Certainly the article by Dr Bergman1 published in 1963 remains a seminal work on poor adherence to penicillin dosaging in the treatment of group A β-hemolytic streptococcal pharyngitis. We agree that compliance may be better in private suburban pediatric practices than in hospital clinics. If all of the many papers from the Elmwood Pediatric Group clinical trials2 on group A β-hemolytic streptococcal pharyngitis comparing various antibiotics and antibiotic regimens were to be reviewed, the overall compliance with the full duration of prescribed therapy would be in the range of 90% to 95%. In our recent article,3 compliance ranged from 87% to 99% as measured on day 5 of treatment based on an assay of antibiotic presence in urine. Virtually identical percentages were confirmed with medication diaries and measurement of remaining medication at the end of the 10-day prescribed treatment courses, so we have evidence to support the notion that nearly all of the penicillin made it to the children's stomachs. Nevertheless, we agree that a full 10-day regimen of penicillin or any antibiotic is an adherence barrier.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles

The Rational Clinical Examination
Make the Diagnosis: Penicillin Allergy

The Rational Clinical Examination
Original Article: Is This Patient Allergic to Penicillin?