As the child matures, a greater variety of questions are commonly asked by pediatricians. With preschool-aged children, pediatricians reported commonly asking questions about school activities, friends, and toys. With school-aged children, questions about the medical history and about the child's life and interests, such as school, family, friends, and food, were commonly asked. Specific substance use and sexual issues are openly discussed with adolescent patients. Substance use issues were, on average, first discussed at the age of 12 years. In both urban and suburban practice settings, discussions of smoking, alcohol, and other drugs were initiated at about the same ages (urban vs suburban means [SDs], 11.6 [2.2] vs 12.0 [2.3], 12.0 [2.3] vs 12.4 [2.1], and 11.8 [2.5] vs 12.2 [2.4] years, respectively; all P>.14), although female pediatricians reported initiating discussion of smoking at an earlier age than did male pediatricians (11.5 [2.5] vs 12.2 [2.0] years; t=2.31, P=.02). The sex-related topics of sexually transmitted diseases (STDs), human immunodeficiency virus (HIV) and AIDS, sexual history, and pregnancy were, on average, first discussed with patients at the age of 13 years (means [SDs], 12.8 [1.5], 12.8 [1.5], 12.9 [1.5], and 13.0 [1.6] years, respectively). However, as shown in Figure 3, pediatricians who practice in urban settings reported first discussing sexual topics with their patients at a significantly earlier age than did pediatricians who practice in suburban settings (all P<.001). In urban settings, discussion of STDs, HIV and AIDS, sexual history, and pregnancy were initiated at mean (SD) ages of 12.4 (1.5), 12.4 (1.6), 12.4 (1.4), and 12.6 (1.5) years, respectively. In suburban settings, discussion of STDs, HIV and AIDS, sexual history, and pregnancy were initiated at mean (SD) ages of 13.2 (1.3), 13.2 (1.3), 13.2 (1.4), and 13.5 (1.5) years, respectively. Moreover, independent of urban and suburban settings, the female pediatricians sampled reported initiating discussion of STDs, sexual history, and pregnancy earlier than did the males (all P<.05). Among female pediatricians, discussion of STDs, sexual history, and pregnancy were initiated at mean (SD) ages of 12.6 (1.5), 12.7 (1.4), and 12.9 (1.6) years, respectively. Among male pediatricians, discussion of STDs, sexual history, and pregnancy were initiated at mean (SD) ages of 13.1 (1.3), 13.1 (1.6), and 13.4 (1.6) years, respectively. There was no difference between female and male pediatricians in the mean (SD) ages at which they initiated discussion of HIV and AIDS (12.6 [1.6] vs 13.0 [1.3] years; t=1.66, P=.098).