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Comment & Response |

Prenatal Antidepressant Use and Risk of Autism Spectrum Disorders in Children

Yusuf Cem Kaplan, MD1,2; Elif Keskin-Arslan, MD1,2; Selin Acar1,2
[+] Author Affiliations
1Department of Pharmacology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey
2Terafar-Izmir Katip Celebi University Teratology Information, Training and Research Center, Izmir, Turkey
JAMA Pediatr. 2016;170(7):712. doi:10.1001/jamapediatrics.2016.0727.
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To the Editor The register-based cohort study by Boukhris et al1 investigating the association between prenatal antidepressant use and risk of autism spectrum disorders (ASD) in the offspring was interesting. The authors reported a significant increase in risk of ASD in children whose mothers were exposed to antidepressants and selective serotonin reuptake inhibitors (SSRIs) in the second and/or third trimesters of their pregnancy. However, we believe that the study suffers from incomplete reporting and discussion of the results, which may lead to significant misinterpretations.

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July 1, 2016
Pascal Bédard, BPharm, MSc
1Department of Pharmacy, Sainte-Justine University Hospital Center, Montréal, Quebec, Canada
JAMA Pediatr. 2016;170(7):712-713. doi:10.1001/jamapediatrics.2016.0730.
July 1, 2016
Alain Lesage, MD, MPhil; Fatoumata Binta Diallo, PhD
1Department of Psychiatry, University of Montreal, Montreal, Québec, Canada2Institut Universitaire en Santé Mentale de Montréal, Montreal, Québec, Canada
2Institut Universitaire en Santé Mentale de Montréal, Montreal, Québec, Canada
JAMA Pediatr. 2016;170(7):714. doi:10.1001/jamapediatrics.2016.0733.
July 1, 2016
Nicholas A. Link, PharmD, BCOP; Mary E. Temple-Cooper, MS, PharmD, BCPS
1Clinical Pharmacy Specialist, Oncology, Hillcrest Hospital, Cleveland Clinic, Mayfield Heights, Ohio
2Clinical Pharmacy Specialist, Obstetrics, Neonatology and Pediatrics. Hillcrest Hospital, Cleveland Clinic, Mayfield Heights, Ohio
JAMA Pediatr. 2016;170(7):713-714. doi:10.1001/jamapediatrics.2016.0736.
July 1, 2016
Keith Fluegge, BA
1Institute of Health and Environmental Research, Cleveland, Ohio
JAMA Pediatr. 2016;170(7):710. doi:10.1001/jamapediatrics.2016.0739.
July 1, 2016
Adrienne Einarson, RN, PhD; Carly Snyder, MD; Gail Robinson, MD, DPsych, FRCPC
1The Reproductive Psychiatry Group, The Hospital for Sick Children (retired), Toronto, Canada
2Health Program, Family Health Associates, Mount Sinai Beth Israel Medical Center, New York, New York3Women's Mental Health Elective, Mount Sinai Beth Israel Medical Center, New York, New York
4Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada5Women's Mental Health Program, University Health Network, Toronto, Ontario, Canada
JAMA Pediatr. 2016;170(7):710-711. doi:10.1001/jamapediatrics.2016.0742.
July 1, 2016
Eric Fombonne, MD
1Department of Psychiatry, Oregon Health and Science University, Portland
JAMA Pediatr. 2016;170(7):711-712. doi:10.1001/jamapediatrics.2016.0745.
July 1, 2016
Anick Bérard, PhD; Takoua Boukhris, MSc
1Faculty of Pharmacy, University of Montreal, Montreal, Quebec, Canada2Research Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada
JAMA Pediatr. 2016;170(7):714-715. doi:10.1001/jamapediatrics.2016.0748.
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