Approximately 1 of every 66 live births in the United States in 2012 were conceived using assisted reproductive technology (ART). Boulet and coauthors examine the prevalence of birth defects among liveborn infants in Florida, Massachusetts, and Michigan from 2000-2010, comparing those born with and without ART. There was a 28% increased risk of nonchromosomal birth defects among infants born through ART. Risks were marginally higher among infants born to mothers with ovulation disorders and in those born through use of assisted hatching. As use of ART continues to increase, careful evaluation of the long-term outcomes of children conceived using these technologies becomes increasingly important.