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Research Letter |

Expression of Circulating Muscarinic Receptors in Infants With Severe Idiopathic Life-Threatening Events

Chris Adamopoulos, MD1; Hugues Greney, PhD2; Maxime Beutelstetter, PharmD3; Pascal Bousquet, MD2; Angelo Livolsi, MD1
[+] Author Affiliations
1Unit of Cardiopediatrics, Hautepierre University Hospital, Strasbourg, France
2Laboratory of Neurobiology and Cardiovascular Pharmacology, Federation of Translational Medicine, University of Strasbourg, Strasbourg, France
3Center of Clinical Investigation, University Hospitals of Strasbourg, Strasbourg, France
JAMA Pediatr. 2016;170(7):707-708. doi:10.1001/jamapediatrics.2015.4762.
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This study investigates the expression of M2 muscarinic receptors’ in the blood samples of infants who experienced apparent life-threatening events.

About half of the apparent life-threatening events (ALTEs) that occur among infants remain unexplained and are called idiopathic.1 Yet there is no biomarker associated with idiopathic ALTEs. Although the connection between ALTEs and sudden infant death syndrome (SIDS) remains controversial, the cholinergic system has been investigated in the pathogenesis of both.24 We investigate the M2 muscarinic receptors’ expression in the blood samples of infants who experienced severe ALTEs.

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Figure.
Muscarinic Receptor (M2) Expression in 3 Groups of Infants

Each symbol represents 1 individual value. The solid lines represent the median values of the groups; the dotted horizontal line represents the highest control value. ALTEs indicates apparent life-threatening events.

aFor nonparametric testing, with adjustment for multiple comparisons.

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