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Comment & Response |

Does Metformin Really Increase Height or Is There Some Problem With the Controls?

Alison Poulton, MA, MBBChir, MD1
[+] Author Affiliations
1The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
JAMA Pediatr. 2016;170(6):620-621. doi:10.1001/jamapediatrics.2015.4962.
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To the Editor I read with interest the meta-analysis by Kuzik et al.1 This study included 10 randomized clinical studies investigating the effects of metformin on height, weight, and body mass index. Meta-analysis of the 5 studies with the highest cumulative dose revealed a rather surprising outcome that the authors described as a “dose-response relationship between metformin use and increases in height.”1 They did not offer any clear hypothesis to explain this finding. In their article, the 2 studies with the greatest contribution to the positive significance of this finding are Kendall et al2 (1-cm difference; weight, 37.3%) and Ibáñez et al3 (3.8-cm difference; weight, 16.7%).


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June 1, 2016
Nicholas Kuzik, MSc; Étienne Myette-Côté, MSc; Normand Boulé, PhD
1Faculty of Physical Education and Recreation, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada2Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
JAMA Pediatr. 2016;170(6):621. doi:10.1001/jamapediatrics.2015.4965.
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