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Melatonin-Induced Nocturnal Vasodilatation Contributes to Skin Regeneration

Igor B. Mekjavic, PhD1; Ian A. Macdonald, PhD2
[+] Author Affiliations
1Department of Automation, Biocybernetics, and Robotics, Jozef Stefan Instititute, Ljubljana, Slovenia
2Medical Research Council and Arthritis Research UK, Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham Medical School, Nottingham, England
JAMA Pediatr. 2016;170(6):621-622. doi:10.1001/jamapediatrics.2016.0131.
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To the Editor The results of the report by Chang et al,1 demonstrating that melatonin supplementation is associated with improved sleep-onset latency and disease severity in children with atopic dermatitis, may provide further insight into the phenomenon of nocturnal peripheral vasodilatation. It is suggested that nocturnal peripheral vasodilatation provides a thermal afferent stimulus emanating from the cutaneous warm sensors to the sleep center, which contributes to the initiation of sleep onset in humans.2,3 The increased heat loss induced by the peripheral vasodilatation causes the decrease in deep body temperature during the night.


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June 1, 2016
Yung-Sen Chang, MD, MPH; Bor-Luen Chiang, MD, PhD
1Department of Pediatrics, Taipei City Hospital Renai Branch, Taipei, Taiwan2Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan3National Yang-Ming University, Taipei, Taiwan
4Department of Pediatrics, National Taiwan University Children’s Hospital, Taipei, Taiwan5Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan6Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
JAMA Pediatr. 2016;170(6):622. doi:10.1001/jamapediatrics.2016.0138.
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