The CDC guideline is now published, without regard for pediatric patients. To address the needs of this age group, we recommend a series of short-, medium-, and long-term strategies. Immediately, the CDC is urged to provide an explicit and definitive statement that this guideline should not be applied to those younger than 18 years of age for fear of untoward consequences. Perhaps the title should be changed to reflect this (eg, 2016 CDC Guideline for Prescribing Opioids for Chronic Pain in Adults). In the medium term, as soon as possible, an expert panel should be assembled to combine available evidence and expert opinion in order to delineate specific indications and safety concerns around the use of opioids for chronic pain in infants, children, and adolescents. We recognize the limitations of the available literature, but many of the adult recommendations were made largely on the basis of expert consensus. In the long term, it is imperative to use developmental methods, including cross-sectional, cross-sequential, and longitudinal designs, to better define risk factors and understand the trajectories that predispose one to problems with chronic pain and substance misuse.12 Future guidelines should embrace a life-span developmental approach to these thorny issues so that our entire population can benefit from these important documents.