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Comment & Response |

Glyburide vs Insulin and Adverse Pregnancy Outcomes—Reply

Wendy Camelo Castillo, MD, PhD1; Michele Jonsson Funk, PhD2
[+] Author Affiliations
1Department of Pharmaceutical Health Services Research, School of Pharmacy, University of Maryland, Baltimore
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill
JAMA Pediatr. 2015;169(10):975. doi:10.1001/jamapediatrics.2015.1811.
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In Reply We thank Feghali et al and Rezai et al for their interest in our article.1 They raise important considerations when interpreting our results. We acknowledge that our measure for obesity is imperfect and that there is the potential for residual confounding. Previous literature has shown that neonatal risk increases gradually with higher maternal weight, and this may also be the case among pharmacologically treated women.2 In light of the inherent heterogeneity among women initiating pharmacological treatment, we need to better understand whether the increased risk for women treated with glyburide (compared with insulin) varies by maternal weight.


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October 1, 2015
Maisa N. Feghali, MD; Christina M. Scifres, MD; Steve N. Caritis, MD
1Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
2Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City
JAMA Pediatr. 2015;169(10):974. doi:10.1001/jamapediatrics.2015.1805.
October 1, 2015
Shadi Rezai, MD; Monica Vielman, MD; Cassandra E. Henderson, MD
1Lincoln Medical and Mental Health Center, Bronx, New York
1Lincoln Medical and Mental Health Center, Bronx, New York2New York Weill Cornell Medical Center, New York
JAMA Pediatr. 2015;169(10):974-975. doi:10.1001/jamapediatrics.2015.1808.
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