Published Online: April 27, 2015. doi:10.1001/jamapediatrics.2015.0214.
Study concept and design: H. Liu, J.-Y. Liu, Zhou.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: H. Liu.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: H. Liu, Feng.
Obtained funding: H. Liu, J.-Y. Liu, Zhou, Yan.
Administrative, technical, or material support: Gu.
Study supervision: J. Liu.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by grants 2012CB944902 and 2012CB944903 from the National Key Basic Research Program of the Ministry of Science and Technology of China, 61020106008 and 30900749 from the National Natural Science Foundation of China, SIPO-201410311640.4 from the Invention Patents Program of State Intellectual Property Office of China, JX10231081 from the Priority Academic Program Development of Jiangsu Higher Education Institutions of China, and SJZZ20140118 from the Graduate Practice Innovation Project of Jiangsu Higher Schools of China.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Zhi-Bin Hu, MD, MPH, PhD, Changjiang Scholars Distinguished Professor, Department of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Laboratory of Modern Toxicology, Nanjing Medical University, for the suggestion of the study design; Zhen Sun, MD, Li Gao, MD, and Yu-Gui Cui, PhD, State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical, in the recruitment and observation of the participants; and are grateful to all children and parents who participated in this study and diligently returned questionnaires. The persons named were not compensated for study assistance beyond their salaries.
Additional Information: The clinicaltrials.gov identifier for this study is NCT02190422. The ethics registration identifier in the Association for the Accreditation of Human Research Protection Program is 2012-SR-048.