Accepted for Publication: January 10, 2015.
Published Online: April 6, 2015. doi:10.1001/jamapediatrics.2015.54.
Study concept and design: Zappitelli, Krawczeski, Devarajan, Parikh.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Zappitelli, Greenberg, Krawczeski, Devarajan, Parikh.
Critical revision of the manuscript for important intellectual content: Zappitelli, Greenberg, Coca, Li, Thiessen-Philbrook, Bennett, Devarajan, Parikh.
Statistical analysis: Zappitelli, Thiessen-Philbrook, Parikh.
Obtained funding: Devarajan, Parikh.
Administrative, technical, or material support: Zappitelli, Krawczeski, Bennett.
Study supervision: Zappitelli, Krawczeski, Bennett, Devarajan, Parikh.
Conflict of Interest Disclosures: Dr Devarajan reported being a coinventor on the neutrophil gelatinase–associated lipocalin patent. Dr Parikh reported being a coinventor on the interleukin 18 patent. No other disclosures were reported.
Funding/Support: Funding to the Cincinnati Children’s Hospital Medical Center Biomarker Laboratory allows for biomarker measurements at cost. Urine biomarker assays were donated by Abbott Diagnostics (interleukin 18 and neutrophil gelatinase–associated lipocalin) and by Sekisui Diagnostics LLC (kidney injury molecule 1 and liver fatty acid–binding protein). This research was supported by grant R01HL-085757 from the National Heart, Lung, and Blood Institute (Dr Parik). Dr Zappitelli was supported by a Career Salary Award from the Fonds de Recherche du Québec–Santé. Dr Coca has been supported by Career Development Award K23DK080132 from the National Institutes of Health. Dr Devarajan is supported by grant P50DK096418 from the National Institutes of Health. Dr Parikh is supported by grant K24DK090203 from the National Institutes of Health. Drs Zappitelli, Coca, Devarajan, and Parikh are members of the National Institutes of Health–sponsored Assess, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Consortium (funded by grant U01DK082185).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: A list of the Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) Consortium investigators is available at http://patr.yale.edu/projects/tribe.aspx#page2.
Additional Contributions: Primary study coordinators Isabel A. Butrymowicz, MD, CCRP (Yale University School of Medicine) and Ana Palijan, PhD (McGill University Health Centre) contributed to study processes and performance. No compensation was provided.