Up-to-date estimates of the health outcomes of preterm children are needed for informing parents, making decisions about care, and providing evidence for clinical guidelines. In this report from the EPIPAGE-2 study cohort, 2205 births and terminations of pregnancy at 22 through 26 weeks’ gestation, 3257 at 27 through 31 weeks, and 1234 at 32 through 34 weeks were studied. A total of 0.7% of infants born before 24 weeks’ gestation survived compared with 31.2% at 24 weeks, 75.3% at 26 weeks, and 98.9% born at 32 through 34 weeks. The proportion of infants surviving without severe morbidity in 2011 increased by 14.4% compared with 1997 for births at 25 through 29 weeks. In his editorial, Marlow discusses the importance and uses of these longitudinal outcome studies of premature infants.