We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Oxygen Therapy for Preterm Neonates The Elusive Optimal Target

Anne Synnes, MDCM, MHSc, FRCPC1; Steven P. Miller, MDCM, MAS, FRCPC2
[+] Author Affiliations
1Division of Neonatology, British Columbia’s Women’s Hospital and Health Centre, Vancouver, British Columbia, Canada
2Department of Pediatrics, The Hospital for Sick Children, and the University of Toronto, Toronto, Ontario, Canada
JAMA Pediatr. 2015;169(4):311-313. doi:10.1001/jamapediatrics.2014.3664.
Text Size: A A A
Published online


Oxygen is the most commonly used “drug” for preterm babies. Oxygen is essential for life. Yet, the too-liberal use of oxygen is toxic.14 The Surfactant, Positive Pressure, and Oxygenation Randomized Trial, the Benefits of Oxygen Saturation Targeting trials, and the Canadian Oxygen Trial (all randomized clinical controlled trials) sought to identify the optimal oxygen saturation target range in extremely preterm neonates (85%-89% vs 91%-95%). At the time that these trials were conducted, the American Academy of Pediatrics recommended using oxygen therapy to maintain peripheral oxygen saturations in the 85% to 95% range. Impressively, all 3 trial groups embarked on rigorously designed trials that would facilitate an eventual meta-analysis. Do we now have an optimal “dose” of oxygen for the preterm neonate?

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

1 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles