Accepted for Publication: November 4, 2014.
Published Online: January 12, 2015. doi:10.1001/jamapediatrics.2014.3158.
Study concept and design: Villarino, Weis, Weiner, Nachman, Oliveira, Shang, Sterling.
Acquisition, analysis, or interpretation of data: Villarino, Scott, Weiner, Conde, Jones, Moro, Shang, Goldberg, Sterling.
Drafting of the manuscript: Villarino, Scott, Weis, Weiner, Nachman, Goldberg, Sterling.
Critical revision of the manuscript for important intellectual content: Villarino, Weiner, Conde, Jones, Nachman, Oliveira, Moro, Shang, Goldberg, Sterling.
Statistical analysis: Villarino, Scott, Shang.
Administrative, technical, or material support: Villarino, Weiner, Nachman, Goldberg.
Study supervision: Villarino, Goldberg, Sterling.
Conflict of Interest Disclosures: Mr Scott and Dr Moro report being employed by the CDC Foundation, which receives funds for rifapentine research from Sanofi. Dr Weiner reports receiving a grant to perform rifapentine pharmacokinetics studies in children and adults for the University of Texas Health Science Center at San Antonio from Sanofi. Dr Sterling reports giving a 1-day consultation for Sanofi for presentation of PREVENT TB study data to the US Food and Drug Administration and being on the data safety monitoring board for a clinical trial sponsored by Otsuka Pharmaceutical. No other disclosures were reported.
Funding/Support: Sanofi provided the rifapentine for this study and has donated more than $2.5 million to the CDC Foundation to supplement available US federal funding for rifapentine research.
Role of the Funder/Sponsor: Sanofi had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: A list of the International Maternal Pediatric and Adolescents AIDS Clinical Trials Group (IMPAACT) and the Tuberculosis Trials Consortium (TBTC) members is included in eAppendix 1 in the Supplement.
Disclaimer: The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the CDC.
Previous Presentation: Preliminary results of this study were presented at ID Week 2012, a Joint Meeting of the Infectious Diseases Society of America, Society for Healthcare Epidemiology of America, HIV Medicine Association, and Pediatric Infectious Diseases Society; October 20, 2012; San Diego, California.
Correction: This article was corrected on July 30, 2015, to fix an incorrect number in Table 2.