Gurney and colleagues used data from the National Survey of Children's Health to examine the extent to which children with an autism spectrum disorder (ASD) have, according to parental report, a higher prevalence of common childhood conditions and health care use than children without an ASD. Children with an ASD had a significantly higher prevalence of depression or anxiety problems and behavioral or conduct problems and reported more respiratory, skin, and food allergies than children without an ASD. These children had higher health care use, especially for physical, occupational, and speech therapy. They were much more likely to need behavioral counseling and to be using long-term medications. The responsibilities that parents bear as they manage the diverse needs of their children with an ASD are enormous.