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Article |

Quality of Life in Adolescent Girls With Polycystic Ovary Syndrome FREE

Maria E. Trent, MD, MPH; Michael Rich, MD, MPH; S. Bryn Austin, ScD; Catherine M. Gordon, MD, MSc
[+] Author Affiliations

From the Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Md (Dr Trent); and Division of Adolescent/Young Adult Medicine, Children's Hospital Boston, Harvard Medical School, Boston, Mass (Drs Rich, Austin, and Gordon).


Arch Pediatr Adolesc Med. 2002;156(6):556-560. doi:10.1001/archpedi.156.6.556.
Text Size: A A A
Published online

Objectives  To examine health-related quality of life (HRQL) in adolescents with polycystic ovary syndrome (PCOS), compared with healthy adolescents, and to determine whether clinically observed or self-perceived severity of illness affects their HRQL.

Design and Setting  Cross-sectional study of female adolescents conducted at an urban, hospital-based adolescent medicine clinical practice.

Participants  Ninety-seven adolescent patients with PCOS and 186 healthy patients who were seen for care between October 15, 1999, and March 2, 2001.

Main Outcome Measures  Health-related quality-of-life scores as determined by the Child Health Questionnaire–Child Self-Report Form.

Results  Adolescents with PCOS scored lower on subscales measuring general health perceptions, physical functioning, general behavior, and limitations in family activities because of illness. Patients scored higher on the change in health in the last year subscale, and most had been diagnosed and initiated treatment for PCOS in the last year. Patients who had higher self-perceived severity of illness also scored lower on the general health perceptions subscale, but clinical severity was not associated with differences in HRQL.

Conclusions  Adolescents with PCOS experience lower HRQL compared with healthy adolescents. Polycystic ovary syndrome and perceived severity of illness negatively affect HRQL in adolescents. This study suggests a need to develop interventions to reduce the distress that patients with PCOS may face as adolescents and young adults.

Figures in this Article

POLYCYSTIC OVARY syndrome (PCOS) occurs in 5% to 10% of women, making it one of the most common endocrine disorders.1,2 The syndrome represents a range of clinical presentations, with variable degrees of severity and physical findings. Common clinical findings of the disorder include irregular menstrual cycles, hirsutism, acne, acanthosis nigricans, obesity, and infertility.3

Polycystic ovary syndrome has a significant effect on adult women, resulting in diminished quality of life, altered feminine identity, and dysfunction in the family and work environment.46 Adolescent patients with PCOS, who are at the height of identity development and awareness of body image, may have a more significant disturbance in quality of life. However, no research to date, to our knowledge, has examined the relationship of PCOS to health-related quality of life (HRQL) in adolescent girls. Anecdotal evidence from clinical practice with this age group suggests that the disorder can disrupt their quality of life. The aims of this study were to examine HRQL in adolescents with PCOS, compared with healthy adolescents, and to determine whether clinically assessed or self-perceived severity of illness affects HRQL.

Participants were recruited from an urban, hospital-based adolescent medicine practice providing primary and specialty health care, including reproductive endocrinology and pediatric and adolescent gynecology. This cross-sectional study used a confidential, 30-minute HRQL instrument and a general health history questionnaire, administered at the end of a clinic visit. Data collection occurred between October 15, 1999, and March 2, 2001. Each adolescent provided informed consent to participate in the study. The Committee on Clinical Investigation at Children's Hospital Boston approved the study protocol. Parental consent was waived because of the confidential nature of many of the visits. Participants were mailed $10 in compensation for their time.

Inclusion criteria for PCOS participants were age 13 to 22 years, with a diagnosis of PCOS as exemplified by hyperandrogenism (clinical or laboratory diagnosis) and menstrual irregularity.7 Adolescents with PCOS were recruited from the primary care practice and referral base. Healthy female adolescents presenting for routine or sports physicals, routine gynecologic care, contraceptive management, or follow-up of a minor medical issue were recruited as comparisons, if they were age 13 to 22 years and did not meet the exclusion criteria outlined in the next paragraph. Although most healthy participants were from the primary care practice, young women referred for routine gynecologic care and contraception were also recruited for the study.

Exclusion criteria for all participants included: (1) a diagnosis of hyperprolactinemia, nonclassical 21-hydroxylase deficiency, or evidence of an androgen-secreting tumor or intersex state; (2) language or cognitive difficulties preventing reliable completion of the questionnaire; or (3) a chronic or acute illness unrelated to PCOS that could potentially affect the participant's quality of life. Patients who were pregnant or were having a medical or mental health crisis at the time of the visit were also excluded from participation. Demographic factors, such as race/ethnicity, insurance status as a proxy for socioeconomic status, and age, were considered to ensure that participants in both groups were representative of our adolescent medicine practice. Blocking was used to oversample certain race/ethnicity groups and to increase statistical power to compare across race/ethnicity groups.

DEMOGRAPHIC VARIABLES

Data were collected on demographic variables, including age, grade in school, and self-defined race/ethnicity. Insurance status was obtained from the computerized scheduling system after patients had been recruited for the study. Clinical variables obtained from the health care provider at the time of the visit included Ferriman-Gallwey8 (FG) score as a measure of hirsutism, global acne (GA) score,9 weight, and height. Body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters.10 Pretreatment hormonal values for dehydroepiandrosterone sulfate and free and total testosterone were collected on PCOS participants. As a part of the general health–history questionnaire, information was collected on timing and irregularity of menstrual cycles; perceived acne, body hair, and weight status; medications and procedures used; and behavior risks.

HRQL MEASURES

The Child Health Questionnaire–Child Self-Report Form (CHQ-CF87) is a self-report questionnaire that was developed and validated at the Health Institute of the New England Medical Center, Boston.11 The tool consists of 12 summated subscales and is designed to measure the physical and psychosocial health of adolescents. The subscales include the following summary measures: (1) change in health in the last year, (2) role/social emotional, (3) role/social behavioral, (4) bodily pain, (5) behavior, (6) mental health, (7) self-esteem, (8) general health perceptions, (9) family activities, (10) family cohesion, (11) physical functioning, and (12) role/social physical.

The items on the CHQ-CF87 are scored from 0 to 100, except for the change in health in the last year and family cohesion variables, which are scored from 1 to 5. Higher scores on these variables indicate health improvement in the last year and better family cohesion, respectively. Higher scores on all other variables indicate better quality of life. This instrument has a record of reliability and validity for evaluating aspects of health that are pertinent across age, gender, health condition, and socioeconomic status in adolescents.12

SEVERITY OF ILLNESS

Clinical severity of illness was a composite of the FG and GA scores and BMI. An FG score of 8 or higher,8 a GA score greater than 0,9 and a BMI of 30 or higher13,14 were used as diagnostic criteria for the clinical factors. Each participant was given 1 point for each clinical factor present and a score of 0 to 3 based on the presence or absence of each of the clinical factors, creating mild (0-1 point), moderate (2 points), and severe (3 points) categories. All patients had a history of menstrual irregularity, as it was one of the inclusion criteria for this arm of the study.

Scores for perceived severity of illness were generated from the participants' answers to the following questions: (1) Do you have acne? (2) How much body hair do you think you have compared with other girls your age (much less, slightly less, no more, slightly more, or much more)? and (3) How do you think of yourself with regard to weight (very underweight, slightly underweight, about the right weight, slightly overweight, very overweight)? A yes response to the acne question, "slightly overweight" or "very overweight" responses about weight, and "slightly more" or "much more" responses to the body hair questions were considered affirmative. Each participant was given 1 point for each factor perceived to be present and a score of 0 to 3 based on the presence or absence of each of these factors, creating mild (0-1 point), moderate (2 points), and severe (3 points) categories.

DATA ANALYSIS

Syntax and technical assistance for tabulating CHQ-CF87 scores were obtained from the author of the instrument. Linear regression analysis was used to determine the mean differences for each quality-of-life subscale and to assess disease severity (clinically observed or self-perceived) as a primary predictor of HRQL. Using the change in estimate method, the roles of race/ethnicity, age, and insurance status were evaluated as potential confounders or effect modifiers, as these factors are beyond the control of the adolescent and theoretically may affect quality of life.

DESCRIPTION OF THE SAMPLE

Four hundred thirteen adolescents who had scheduled medical appointments were asked if they would be willing to participate in the study. The refusal rate among all girls asked to participate in the study was 7.3% (n = 8) among the PCOS group and 26.4% (n = 69) among the healthy comparison group. The most common reason for refusal was lack of time.

Two hundred ninety-three patients were recruited, of whom 283 met all eligibility criteria for inclusion in the study. The mean ± SD age of all participants was 16.9 ± 2.3 years. There were no significant differences between the PCOS and healthy groups with regard to race/ethnicity, age, or insurance status (Table 1). One hundred one patients with PCOS were enrolled in the study, and 4 were later excluded because they did not meet all eligibility criteria. One hundred ninety-two healthy patients were enrolled in the study, and 6 were later excluded because they did not meet all eligibility criteria.

CLINICAL VARIABLES

The mean BMI and FG and GA scrores were higher for the patient group (Table 2). The mean age at diagnosis of PCOS was 15.1 years, and 51 (60%) of the 85 patients had been diagnosed within the last year. Eighty-three percent (70/84) of the patients had elevated free testosterone, 47% (42/89) had elevated total testosterone, and 29% (24/84) had elevated dehydroepiandrosterone sulfate levels before initiation of treatment.

Table Graphic Jump LocationTable 2. Differences in Clinical Variables and Age Between Patients With Polycystic Ovary Syndrome (PCOS) and Healthy Peers*
PCOS STATUS AS A PREDICTOR OF QUALITY OF LIFE

Compared with healthy adolescents, participants with PCOS scored 0.3 points higher on the change in health in the last year subscale, 7.7 points lower on the general health perceptions subscale, 2.9 points lower on the behavior subscale, 4.1 points lower on the physical functioning subscale, and 6.0 points lower on the family activities subscale. The patients showed a trend toward lower mean scores on the mental health subscale, but this difference was marginally significant (Table 3).

Table Graphic Jump LocationTable 3. Mean Quality-of-Life Scores on Child Health Questionnaire–Child Form 87 and Differences as Determined by Linear Regression Models*
SEVERITY OF ILLNESS

The mean FG and GA scores, BMI, and free testosterone among the PCOS group increased in a stepwise fashion with mild, moderate, and severe PCOS, supporting the rationale of the summary measure for clinical severity (Figure 1). There were, however, no significant differences in HRQL outcomes among patients in the mild, moderate, and severe clinical severity categories.

Place holder to copy figure label and caption

Stepwise increase in mean body mass index (BMI), Ferriman-Gallwey (FG) score, global acne (GA) score, and free testosterone (FT) (in picograms per milliliter) for mild, moderate, and severe clinical severity levels among patients with polycystic ovary syndrome.

Graphic Jump Location

Patient scores for perceived severity of PCOS ranged only in the mild to moderate categories. Controlling for race/ethnicity, patients with perceived moderate severity scored 7.9 points lower on general health perceptions than those with mild disease (β, 7.9; SE β, 3.6; P<.03).

This study demonstrates that adolescents with PCOS had lower HRQL scores on the CHQ-CF87 than healthy comparisons in the areas of general health perceptions, physical functioning, behavior, and family activities. Most participants in this study perceived their illness to be mild, despite the finding that 69% (67/97) had moderate (n = 35) to severe (n = 32) clinical severity scores. In terms of patients' ability to cope with PCOS, it was encouraging that they perceived their severity of illness as mild or moderate. Compared with the clinical assessment, their perception of illness severity correlated more directly with their quality of life with PCOS.

The absence of a direct relationship between clinical severity of illness and quality of life may be explained by several reasons: (1) clinical severity of illness may not be associated with quality of life, (2) there may be an unmeasured confounder, or (3) there was not enough power to detect a difference between groups.

These results must be interpreted in light of acknowledged limitations. Not every patient who was eligible participated in the study, and there were different rates of participation between the PCOS (93%) and healthy (74%) samples. It is unknown whether patients who did not return for their appointments or who were not asked to participate by health care providers were comparable to those who were enrolled. It is possible that participants who had PCOS but did not have menstrual abnormality significant enough to merit clinical evaluation may have been included in the healthy group. However, this would bias the study results toward the null hypothesis. Finally, this is a cross-sectional study, and causality cannot be inferred from the associations found.

Health-related quality of life is a critical outcome measure for any patient, but it may be particularly important for adolescents and young adults with chronic conditions who must cope with and manage their condition for extended periods. It has been used as a key outcome measure in pediatric studies of chronic renal disease,12 asthma,15 allergic rhinitis,16 cystic fibrosis,17 and childhood cancers.18,19 Although clinical criteria measure the magnitude of physiologic dysfunction, they do not capture the physical, emotional, and social effects on the lives of those who live with the disease. This is supported by our finding that the patient's perception rather than the clinician's assessment of PCOS is more relevant to HRQL. Clinicians who serve adolescents and young adults should know that factors other than treatment of disease affect HRQL. As a result, HRQL is an increasingly important outcome measure in child, adolescent, and young adult health.

The social predicaments and developmental tasks that all adolescents face may mediate a patient's ability to cope with PCOS, as adolescent girls look to their peers for validation.20 For example, although a girl may have acne secondary to her PCOS, she may not perceive herself as being different from her peers, given that acne is common in adolescence.21 Obesity is also increasingly common among adolescent girls without PCOS.13,14 Individual factors or a combination of factors, including the milieu of adolescence, may therefore mediate the quality-of-life experience of patients with PCOS in this age group.

This study supports the hypothesis that adolescents with PCOS experience lower quality of life compared with healthy adolescents. Most important, it is the patient's perceived rather than the clinician's assessed severity of illness that negatively affects quality of life. This study suggests potential areas of investigation and intervention in the field of adolescent PCOS. Patients noted a greater change in their overall health in the last year compared with their healthy peers, which suggests a positive role of medical intervention in their lives. Health services research that examines the timing of diagnosis and initiation of treatment, variability in treatment approaches, and patient–health care provider communication may also be instrumental in understanding the long-term health and quality-of-life outcomes in adolescents with PCOS. This study also suggests the need to develop supportive interventions that address quality-of-life issues to reduce the distress that patients with PCOS may face as adolescents and young adults.

Accepted for publication February 7, 2002.

This study was supported by project 6T71MC00009-09S1R0 from the Maternal and Child Health Bureau (Title V, Social Security Act), Health Resources and Services Administration, US Department of Health and Human Services, Rockville, Md, and by an unrestricted educational grant from Aventis Pharmaceuticals, Inc, Bridgewater, NJ.

We thank the members of the Divisions of Adolescent/Young Adult Medicine and Gynecology at Children's Hospital Boston for their role in patient recruitment. In addition, we thank S. Jean Emans, MD, for her input on this project, Jeanne Landgraf, MA, for her guidance in analyzing the CHQ-CF87, Kelly Becker, BA, for her role as research assistant, and Wendy Yang, BS, for SPSS technical expertise.

What This Study Adds

Polycystic ovary syndrome has considerable effects on the lives of adult women; however, to our knowledge, research has not previously investigated the potential effects on the health-related quality of life of adolescents with this illness. This study examined health-related quality of life in patients in this age group with PCOS compared with healthy peers. It demonstrates that PCOS and higher self-perceived severity of illness negatively affect quality of life in these patients. This study also provides direction toward potential areas of investigation and intervention in the field of adolescent PCOS, aimed at reduction of the significant quality-of-life disturbance these patients may face as adolescents and young adults.

Corresponding author and reprints: Maria E. Trent, MD, MPH, Division of Pediatrics and Adolescent Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, Park 307, 600 N Wolfe St, Baltimore, MD 21287 (e-mail: mtrent2@jhmi.edu).

Franks  S Polycystic ovary syndrome. N Engl J Med. 1995;333853- 859
Link to Article
Knochenhauer  TKey  JKahsar-Miller  MWaggoner  WBoots  LRAzziz  R Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998;833078- 3082
Emans  SLaufer  MGoldstein  DP Pediatric and Adolescent Gynecology.  Philadelphia, Pa Lippincott Williams & Wilkins1998;263- 301
Paulson  J An investigation of the relationship between emotional maladjustment and infertility. Fertil Steril. 1988;49258- 262
Somino  NFava  GMani  E Quality of life of hirsute women. Postgrad Med J. 1993;69189- 196
Cronin  LGuyatt  GGriffith  L  et al.  Development of a health-related quality-of-life questionnaire (PCOSQ) for women with polycystic ovary syndrome (PCOS). J Clin Endocrinol Metab. 1998;831976- 1987
Zawadzki  JKDunaif  ADunaif  AedGivens  JRedHaseline  FedMerriam  GRed Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Polycystic Ovary Syndrome Boston, Mass Blackwell Publishers1992;377- 384
Ferriman  DGallwey  J Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 1961;211440- 1447
Link to Article
Doshi  AZaheer  AStiller  MJ A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997;36416- 418
Link to Article
Troiano  RPFlegal  KM Overweight children and adolescents: description, epidemiology, and demographics. Pediatrics. 1998;101(suppl)S497- S504
Landgraf  JMAbetz  LWare  JE The CHQ User's Manual.  Boston, Mass Health Institute, New England Medical Center1996;
Kurtin  PSLandgraf  JMAbetz  L Patient-based health status measurements in pediatric dialysis: expanding the assessment of outcome. Am J Kidney Dis. 1994;24376- 382
Link to Article
Himes  JHDeitz  WH Guidelines for overweight in adolescent preventive services: recommendations from an expert committee. Am J Clin Nutr. 1994;59307- 316
Barlow  SEDietz  WH Obesity evaluation and treatment: expert committee recommendations. Pediatrics. [serial online]1998;102e29Available athttp://www.pediatrics.org/cgi/content/full/102/3/e29Accessed March 19, 2002
Link to Article
Juniper  EFGuyatt  GHFeeny  DHFerrie  PJGriffith  LETownsend  M Measuring quality of life in children with asthma. Qual Life Res. 1996;535- 46
Link to Article
Juniper  EF Measuring health-related quality of life in rhinitis. J Allergy Clin Immunol. 1997;99(suppl)S742- S749
Link to Article
Powers  PMGerstle  RLapey  A Adolescents with cystic fibrosis: family reports of health-related quality of life and forced expiratory volume in one second. Pediatrics. [serial online]2001;107e70Available athttp://www.pediatrics.org/cgi/content/full/107/5/e70Accessed March 19, 2002
Link to Article
Sawyer  MAntoniou  GToogood  IRice  M A comparison of parent and adolescent reports describing the health-related quality of life of adolescents treated for cancer. Int J Cancer Suppl. 1999;1239- 45
Link to Article
Landgraf  JM Measuring health-related quality of life in pediatric oncology patients: a brief commentary on the state of the art measurement and application. Int J Cancer Suppl. 1999;12147- 150
Link to Article
Neumark-Sztainer  D The social environments of adolescents: associations between socioenvironmental factors and health behaviors during adolescence. Adolesc Med. 1999;1041- 55
Rosenfield  RLLucky  AW Acne, hirsutism, and alopecia in adolescent girls: clinical expressions of androgen excess. Endocrinol Metab Clin North Am. 1993;22507- 532

Figures

Place holder to copy figure label and caption

Stepwise increase in mean body mass index (BMI), Ferriman-Gallwey (FG) score, global acne (GA) score, and free testosterone (FT) (in picograms per milliliter) for mild, moderate, and severe clinical severity levels among patients with polycystic ovary syndrome.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 2. Differences in Clinical Variables and Age Between Patients With Polycystic Ovary Syndrome (PCOS) and Healthy Peers*
Table Graphic Jump LocationTable 3. Mean Quality-of-Life Scores on Child Health Questionnaire–Child Form 87 and Differences as Determined by Linear Regression Models*

References

Franks  S Polycystic ovary syndrome. N Engl J Med. 1995;333853- 859
Link to Article
Knochenhauer  TKey  JKahsar-Miller  MWaggoner  WBoots  LRAzziz  R Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998;833078- 3082
Emans  SLaufer  MGoldstein  DP Pediatric and Adolescent Gynecology.  Philadelphia, Pa Lippincott Williams & Wilkins1998;263- 301
Paulson  J An investigation of the relationship between emotional maladjustment and infertility. Fertil Steril. 1988;49258- 262
Somino  NFava  GMani  E Quality of life of hirsute women. Postgrad Med J. 1993;69189- 196
Cronin  LGuyatt  GGriffith  L  et al.  Development of a health-related quality-of-life questionnaire (PCOSQ) for women with polycystic ovary syndrome (PCOS). J Clin Endocrinol Metab. 1998;831976- 1987
Zawadzki  JKDunaif  ADunaif  AedGivens  JRedHaseline  FedMerriam  GRed Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Polycystic Ovary Syndrome Boston, Mass Blackwell Publishers1992;377- 384
Ferriman  DGallwey  J Clinical assessment of body hair growth in women. J Clin Endocrinol Metab. 1961;211440- 1447
Link to Article
Doshi  AZaheer  AStiller  MJ A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997;36416- 418
Link to Article
Troiano  RPFlegal  KM Overweight children and adolescents: description, epidemiology, and demographics. Pediatrics. 1998;101(suppl)S497- S504
Landgraf  JMAbetz  LWare  JE The CHQ User's Manual.  Boston, Mass Health Institute, New England Medical Center1996;
Kurtin  PSLandgraf  JMAbetz  L Patient-based health status measurements in pediatric dialysis: expanding the assessment of outcome. Am J Kidney Dis. 1994;24376- 382
Link to Article
Himes  JHDeitz  WH Guidelines for overweight in adolescent preventive services: recommendations from an expert committee. Am J Clin Nutr. 1994;59307- 316
Barlow  SEDietz  WH Obesity evaluation and treatment: expert committee recommendations. Pediatrics. [serial online]1998;102e29Available athttp://www.pediatrics.org/cgi/content/full/102/3/e29Accessed March 19, 2002
Link to Article
Juniper  EFGuyatt  GHFeeny  DHFerrie  PJGriffith  LETownsend  M Measuring quality of life in children with asthma. Qual Life Res. 1996;535- 46
Link to Article
Juniper  EF Measuring health-related quality of life in rhinitis. J Allergy Clin Immunol. 1997;99(suppl)S742- S749
Link to Article
Powers  PMGerstle  RLapey  A Adolescents with cystic fibrosis: family reports of health-related quality of life and forced expiratory volume in one second. Pediatrics. [serial online]2001;107e70Available athttp://www.pediatrics.org/cgi/content/full/107/5/e70Accessed March 19, 2002
Link to Article
Sawyer  MAntoniou  GToogood  IRice  M A comparison of parent and adolescent reports describing the health-related quality of life of adolescents treated for cancer. Int J Cancer Suppl. 1999;1239- 45
Link to Article
Landgraf  JM Measuring health-related quality of life in pediatric oncology patients: a brief commentary on the state of the art measurement and application. Int J Cancer Suppl. 1999;12147- 150
Link to Article
Neumark-Sztainer  D The social environments of adolescents: associations between socioenvironmental factors and health behaviors during adolescence. Adolesc Med. 1999;1041- 55
Rosenfield  RLLucky  AW Acne, hirsutism, and alopecia in adolescent girls: clinical expressions of androgen excess. Endocrinol Metab Clin North Am. 1993;22507- 532

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