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Article |

Abstracts of Randomized Controlled Trials Presented at the Society for Pediatric Research Meeting:  An Example of Publication Bias FREE

Terry P. Klassen, MD; Natasha Wiebe, MMath; Kelly Russell, BSc; Kelly Stevens, BSc; Lisa Hartling, MSc; William R. Craig, MD; David Moher, MSc
[+] Author Affiliations

From the Department of Pediatrics, University of Alberta, and the Alberta Research Centre for Child Health Evidence, Edmonton (Drs Klassen and Craig and Mss Wiebe, Russell, Stevens, and Hartling); and the Thomas C. Chalmers Centre for Systematic Reviews, Children's Hospital of Eastern Ontario, University of Ottawa (Mr Moher).


Arch Pediatr Adolesc Med. 2002;156(5):474-479. doi:10.1001/archpedi.156.5.474.
Text Size: A A A
Published online

Background  Publication bias toward studies that favor new therapies has been known to occur for the past 40 years, yet its implications are not well studied in child health. The increased interest in meta-analyses has highlighted the need to identify the totality of evidence when addressing treatment questions.

Objectives  To measure the percentage of randomized controlled trials (RCTs) presented at a major pediatric scientific meeting that were subsequently published as full-length articles, to investigate factors associated with publication, and to describe the variables that change from abstract to manuscript form.

Design  The scientific proceedings from the Society for Pediatric Research were hand searched for RCTs (1992-1995). Subsequent publication was ascertained through a search of various electronic databases. Quality of abstracts and manuscripts was measured, and data were extracted using a structured form.

Results  A total of 264 (59.1%) of 447 abstracts were subsequently published. Almost 64% of RCTs that were subsequently published favored new therapy compared with 43.5% of studies that were never published (P<.001). Mean effect size for published vs unpublished RCTs was 0.74 vs 0.05 (P<.001). Median sample size was larger in published (n = 45) vs unpublished (n = 34) RCTs (P = .02). Quality was significantly lower for abstracts vs published RCTs (P<.001). For 5% of abstracts that were subsequently published, the conclusion regarding treatment efficacy changed.

Conclusions  Publication bias is a serious threat to assessing the effectiveness of interventions in child health, as little more than half of RCTs presented at a major scientific meeting are subsequently published. There is a need to institute an international registry of RCTs in children so that the totality of evidence can be accessed when assessing treatment effectiveness.

Figures in this Article

PUBLICATION BIAS, or the selective publication of studies that favor new therapies, poses a serious threat to validly assessing the effectiveness of new therapies.1 To practice evidence-based medicine, the totality of evidence for and against a new therapy needs to be considered. The selective publication or submission of only those manuscripts that show a beneficial effect of therapy has important implications on the pool of evidence available on which to base decisions. This has implications for the individual clinician and for researchers who aim to synthesize existing evidence in the form of a systematic review.

In a recent meta-analysis evaluating the effectiveness of glucocorticoids for children with croup, Ausejo et al2 demonstrated the challenge of selective publication. Formal statistical testing showed that studies with smaller sample sizes tended to show larger positive effects of an intervention. One plausible explanation for this observation is publication bias.3 This finding casts uncertainty on the degree of benefit conferred on patients with croup from glucocorticoids compared with placebo. McAuley and colleagues4 showed that excluding the gray literature (ie, literature that is difficult to identify or retrieve, of which abstracts form the largest proportion at 61%) may yield larger estimates in meta-analyses by 15%.

Scientific meetings are often the first forum in which new research is shared with one's peers; hence, they represent a unique opportunity to examine the nature and existence of selective publication.5,6 We undertook this study to (1) measure the percentage of randomized trials presented at a major pediatric scientific meeting that were subsequently published, (2) investigate factors associated with publication, and (3) describe the variables that changed from abstract to manuscript form.

SELECTION OF ABSTRACTS AND MANUSCRIPTS

Abstracts of randomized controlled trials (RCTs) were identified by hand-searching the proceedings from the Society for Pediatric Research (1992-1995). To determine whether an abstract was later published in manuscript form, the following databases were searched between February 1 and July 31, 2000: PubMed, EMBASE, Cochrane Library, CINAHL, Web of Science, Current Contents, and HEALTHSTAR. The databases were searched with the assistance of a medical librarian using the name of the primary author and key words found in the title. At least one common outcome must have been found in the abstract and the manuscript to be considered as the corresponding manuscript. If a relevant citation was not found in any of the databases, we assumed that the study had not been published in manuscript form.

Abstracts and manuscripts were included if they reported phase III RCTs with pediatric outcomes (studies reporting outcomes on pregnant women were excluded). Studies were excluded if they reported outcomes of nonrandomized treatment arms only.

ASSESSMENT OF METHODOLOGICAL QUALITY

The quality, or internal validity, of the abstracts and manuscripts was assessed in 3 ways. First, study quality was scored according to a validated 5-point scale developed by Jadad et al.7 This scale is composed of 5 questions to determine whether (1) the study was described as randomized, (2) an appropriate method of randomization was used (eg, table of random numbers), (3) the study was described as double blinded, (4) blinding was appropriate (eg, identical placebo), and (5) there was an adequate description of withdrawals and dropouts. A score of 5 indicates a high-quality study.7 Second, concealment of allocation, or the method used to prevent foreknowledge of group assignment by the patients and the investigators, was assessed. Allocation concealment was rated as adequate (eg, centralized or pharmacy-controlled randomization), inadequate (ie, any procedure that is transparent before allocation, such as an open list of random numbers), or unclear or not reported.8 Third, funding source was recorded as pharmaceutical, government, private, other, or unclear or not reported.

DATA EXTRACTION

The following information was recorded for abstracts and manuscripts: journal citation, year of publication, diagnostic category (as designated in the proceedings of the Society for Pediatric Research), trial design (ie, parallel or crossover), study type (ie, efficacy vs equivalency), stage of study (ie, preliminary or completed), pilot study vs full trial, number of withdrawals, and results.

The overall study conclusions (ie, favored the intervention or not) were determined by the authors' statements in their concluding remarks. If the study favored an intervention, the efficacious treatment was noted. Primary outcomes were determined in 1 of 3 ways: stated by the authors (19.9%), inferred by the extractors through the title or concluding remarks (32.2%), or randomly selected from probable primary outcomes using a computer-generated table of random numbers (47.9%).

Study type was defined according to the authors' statements with respect to the primary hypothesis. If the authors intended to demonstrate a significant difference between treatments, the study type was recorded as efficacy. Equivalence was deemed the study type when authors intended to show that there was no significant difference between treatments.

STATISTICAL ANALYSIS

Data were entered into a database program (Access; Microsoft Corp, Redmond, Wash) and were analyzed using a statistical package (S-PLUS 2000; MathSoft Inc, Cambridge, Mass). Medians and interquartile ranges were used to describe nonparametric data, means and SDs were used for normal continuous data, and percentages and 95% confidence intervals (CIs) were used for dichotomous and categorical data. Odds ratios were converted into effect sizes using a method devised by Hasselblad and Hedges.9 Percentages and their associated 95% CIs were also calculated for descriptive purposes and to quantify the change in variables from abstract to manuscript. To measure the association between different variables and publication status, the following tests were used: Pearson χ2 tests for dichotomous and other categorical data, t tests (Welch modified for unequal variances) for normal continuous data, and Wilcoxon rank sum tests for otherwise nonparametric data. Logistic regression was used to evaluate predictors of publication while controlling for possible confounders such as overall study conclusions and study type. We expected that overall study conclusions would interact with study type. Thus, without the interaction term, study type might reduce the benefit attributed to the overall study conclusions. Log-rank tests were used to assess time to publication. Funnel plots (sample size vs effect size), the rank correlation test,10 and weighted regression3 were used to determine publication bias.

SAMPLE

A total of 447 abstracts were identified; 264 (59.1%; 95% CI, 54.4%-63.7%) were found as published manuscripts. Table 1 gives the number of abstracts identified and the percentage published in manuscript form, by year.

Table Graphic Jump LocationTable 1. Abstracts Published in Manuscript Form, by Year*

Sixteen manuscripts were excluded for the following reasons: not being RCTs (n = 10, although their abstracts claimed randomization), cluster designs (n = 2), data authenticity questioned by the journal editors (n = 2), unavailable methods (n = 1), and study presented as a brief communication (n = 1). The additional information gained by reading the manuscripts was not used to exclude abstracts because further information was not available for abstracts not subsequently published. The included manuscripts (n = 248) were used exclusively in the change in variables (from abstract to manuscript form) analysis. The other analyses were based entirely on abstract data.

Abstracts were classified into 26 diagnostic categories. The most common categories were neonatology-general (24.6% of abstracts that remained unpublished and 23.1% of those that were subsequently published), neonatal pulmonology (14.8% of those unpublished and 12.9% of those published), neonatal nutrition and metabolism (12.6% of those unpublished and 11.4% of those published), and infectious diseases (7.1% of those unpublished and 10.6% of those published). The remaining categories were used for less than 10% of either type of abstract.

Manuscripts were published in 62 journals: 24.2% in Journal of Pediatrics, 20.6% in Pediatrics, and the remaining 55.2% in a variety of journals (with ≤4.0% in any one journal).

There were few abstracts on pilot studies (3.3% of unpublished abstracts and 2.3% of published abstracts) or studies in their preliminary stages (8.2% of unpublished abstracts and 7.6% of published abstracts). The number of withdrawals was reported in only 6.0% and 3.4% of unpublished and published abstracts, respectively. These variables were not considered in the logistic regression analysis.

QUALITY OF ABSTRACTS AND MANUSCRIPTS

Table 2 summarizes study quality by document type. There were no differences in quality measures between abstracts that were subsequently published and those that remained unpublished. Scores on the quality variables were significantly different for all abstracts compared with published manuscripts. Quality variables were not associated with overall study conclusions favoring the new therapy (Jadad score, P = .85; funding source, P = .81).

Table Graphic Jump LocationTable 2. Quality Variables by Document Type*
PREDICTORS OF PUBLICATION

Table 3 provides the results of univariate analyses assessing predictors of publication. Variables associated with publication were study conclusions favoring treatment (63.5% vs 43.7%; P<.001), sample size (n = 45 vs 34; P = .02), and measures of treatment effect. Measures of treatment effect were evaluated in 3 ways: odds ratios for dichotomous outcomes (P = .009), standardized mean differences for continuous outcomes (P = .01), and overall effect sizes (odds ratios and standardized mean differences combined) (P<.001).

Table Graphic Jump LocationTable 3. Predictors of Publication: Univariate Results*

Table 4 gives the results of logistic regression analysis of predictors of publication. The interaction between study type and overall study conclusions was significant. Successful equivalency studies, that is, studies in which the statistical results were nonsignificant, thereby agreeing with the study hypothesis, had the greatest odds of being published. Sample size was also significant, with the chances of publication increasing with larger sample size. Because the distribution of sample size was strongly skewed to the right, greater and greater increases are demanded to produce an equivalent predicting effect. This diminishing return is captured by a log-log transformation of the sample size variable. Effect size was not put into the model because its properties were closely associated with overall study conclusions.

Table Graphic Jump LocationTable 4. Predictors of Publication: Results From Logistic Regression (n = 343)*
VARIABLES THAT CHANGE FROM THE ABSTRACT TO THE PUBLISHED MANUSCRIPT

Two hundred forty-eight abstracts were paired with their subsequent manuscripts. Of these, 239 had conclusions favoring treatment; 2.1% changed from favoring treatment in the abstract to not favoring treatment in the manuscript, whereas 2.9% changed from not favoring treatment in the abstract to favoring treatment in the manuscript.

Most measures of treatment effect changed slightly from the abstract to the manuscript. Thirty-eight percent and 45.1% decreased in log odds ratios and standardized mean differences, respectively, whereas 44.0% and 37.3% increased. Overall significance in effect size was also evaluated (P≤.05). In 4.0% of the cases, abstract outcomes were significant but changed to nonsignificant in manuscript form; 8.9% changed from nonsignificant to significant. In 10.8% of studies, the sample size decreased from the abstract to the manuscript, whereas in 48.3% the sample size increased.

TIME TO PUBLICATION

Figure 1 shows the time to publication by overall study conclusions. The probability of publication plateaued after approximately 60 months. After 5 years, 34.2% of studies with significant findings remained unpublished compared with 55.7% of studies with nonsignificant results.

Place holder to copy figure label and caption
Figure 1.

Time to publication by significant and nonsignificant findings.

Graphic Jump Location

Of studies that were subsequently published, abstracts with Jadad scores of 1 or less were published on average 24.7 months after the abstract appeared in the proceedings of the Society for Pediatric Research compared with 21.3 months for those with scores greater than 1 (P = .11). There was a significant difference between abstracts that did not report a funding source (25.1 months) and those that did (20.9 months) (P = .049). Favoring the new therapy was not associated with time to publication (P = .74).

PUBLICATION BIAS

Figure 2 and Figure 3 show funnel plots for published and unpublished studies. In the absence of publication bias, the funnel plot should resemble an inverted funnel. Smaller studies naturally (or statistically) give a wide range of effect sizes; they are less stable because they contain less information. Thus, at the base of the inverted funnel, one would expect to see the widest spread. At the top of the plot, the effect sizes should converge at a point, if there exists a trial that is sufficiently large to be relatively stable. The funnel plot of published studies (Figure 2) and statistical tests for publication bias show that small unsuccessful studies are less likely to be published (rank correlation test, P = .03; weighted regression, P = .02); the base of the inverted funnel is not balanced, resulting in funnel plot asymmetry. No asymmetry was observed in the sample of studies that were not subsequently published (rank correlation test, P = .43; weighted regression, P = .62) (Figure 3). All studies combined (Figure 3) suggest evidence of publication bias that predates submission to the pediatric meeting (rank correlation test, P = .07; weighted regression, P = .02). Missing studies favoring the control groups are indicated by the asymmetry of the plot. Publication bias may include nonsubmission of studies to the meetings or to journals (submission bias) and rejection of submissions by editorial staff (publication bias).

Place holder to copy figure label and caption
Figure 2.

Funnel plot of published studies. Outliers: −9.4, 25; −5.1, 14; −1.4, 6794; −0.6, 2342; −0.2, 5699; and 0.1, 2416.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Funnel plot of all studies. Outliers: −9.4, 25; −5.1, 14; −1.4, 6794; −0.6, 2342; −0.2, 5699; 0.1, 2416; and 10.8, 7.

Graphic Jump Location

The results of this study demonstrate that a major factor predicting publication after presentation of an RCT at a scientific meeting is a positive outcome favoring the new therapy. The larger the treatment effect, the more likely that a study will be published. This is the first time to our knowledge that this has been shown in the area of child health but is consistent with results of studies in other areas.1,11,12 One implication of this finding is that by using only the published literature to examine the effectiveness of a new therapy, one could get an inflated view of the benefit of a new therapy. Even more worrisome is to conclude that a treatment is effective when if the totality of evidence had been identified (published and unpublished) it may indeed not be better than existing treatments.

It is not known how many RCTs performed in children are never submitted to a scientific meeting. Although the collection of RCTs presented at scientific meetings does not capture the entire universe of RCTs performed in children, it does provide a useful filter to examine the question of publication bias. The funnel plot of all studies submitted to the Society for Pediatric Research meeting indicates that submission bias exists (Figure 3), albeit this bias is less pronounced than in studies that are published as full manuscripts (Figure 2).

The results of our analyses indicate that studies with negative findings are less likely to be published. Stern and Simes13 examined clinical trials approved by a research ethics board for 10 years and found that the hazard ratio for studies with positive vs negative findings being published was 3.13 (P<.001). Scherer and colleagues14 conducted a meta-analysis on studies that documented the proportion of studies published after presentation at a scientific meeting and found an overall estimate of 51%, which is similar to our estimate of 59.1%. Two of these studies, in the areas of ophthalmology and perinatology, were confined to RCTs, and reported publication rates were 61% and 36%, respectively.

Several options have been proposed to minimize publication bias. An international registry of RCTs has been suggested1,15,16 whereby all trials would be registered at their inception. A standard method of identifying trials for registration would be through ethics review boards, as all trials require ethics approval before beginning. Recently, an amnesty for authors of unpublished trials was initiated. One hundred medical journals solicited information on unpublished research by requesting authors to complete an unreported trial registration form.17 This initiative had modest results, with 165 trials involving 32 000 participants being registered within the first year.18

Until publication bias can be fully prevented, there is a need to quantify its existence and to interpret study findings accordingly. Methods have been developed for the detection of publication bias, but they lack sufficient statistical power in meta-analyses with fewer than 10 trials.19 In addition, their performance varies with factors such as sample size, number of trials, and size of treatment effect.20,21

Publication bias may be more frequent in child health as sample sizes are smaller than those in the general literature. Smaller sample sizes mean more statistical fluctuation, hence the probability that small studies may show large treatment effects. Small studies with large treatment effects that favor new therapies are more likely to be published than those that do not favor new therapies. It would be prudent for researchers in child health to move toward larger multicenter trials whenever possible to avoid this "small study effect."

In a survey of editors, 30% of them said they would not publish a meta-analysis that included unpublished research.22 The meta-analyst is caught in a dilemma, as excluding abstracts or other unpublished RCTs means the meta-analysis may be biased toward favoring treatment. McAuley et al4 demonstrated that the average quality of abstracts was lower than full manuscript reports of RCTs. They could not determine whether this was because lower-quality RCTs were not published or whether, as we demonstrate, the lower-quality assessments are because of limited information contained in an abstract. In our study, most abstracts (76%) had a Jadad score of 1. We know that with published manuscripts, RCTs that score less than 2 may have treatment effects 30% larger than high-quality studies (score >2).23 The lack of complete reporting holds true for allocation concealment, as 100% of the abstracts had unclear allocation concealment. A structured reporting system for abstracts of RCTs that would require the author to document these key areas would help solve this problem without greatly increasing the length requirements of abstracts. This has worked well for reporting of RCTs in journals, and the adoption of these guidelines by journals has improved their quality of reporting.22,24 Another solution would be an international registry of trials that would allow meta-analysts to access longer and more detailed versions of the RCT study report in a database.

Despite what has been known about publication bias for 40 years,25 it remains a threat to assessing the validity of therapy in child health. It is urgent that funding agencies, governmental bodies, health administrators, researchers, and clinicians join together to eliminate this important and serious bias.

Accepted for publication January 10, 2002.

What This Study Adds

What Is Already Known and Why This Study Needed to Be Done

  • Publication bias is a serious threat to assessing new therapies

  • The probability of bias increases if the study demonstrates greater benefit for the new therapy, hence seriously undermining our confidence in the published record of evidence as a true estimate of benefit

What This Study Adds to Medical Information and Its Implications

  • This study demonstrates that publication bias is also a significant issue in child health as 40% of trials presented at a scientific meeting are not published

  • When synthesizing therapy evidence, it is critical to assess for the possibility of publication bias

  • Prevention of publication bias could occur if all randomized trials performed in children were mandated to undergo international registration at the time of ethics approval

Corresponding author and reprints: Terry P. Klassen, MD, Department of Pediatrics, University of Alberta, 2C3.67 Walter C. Mackenzie Centre, Edmonton, Alberta, Canada T6G 2B7 (e-mail: terry.klassen@ualberta.ca).

Simes  RJ Publication bias: the case for an international registry of clinical trials. J Clin Oncol. 1986;41529- 1541
Ausejo  MSaenz  APham  B  et al.  The effectiveness of glucocorticoids in treating croup. BMJ. 1999;319595- 600
Link to Article
Egger  MSmith  GDSchneider  MMinder  C Bias in meta-analysis detected by a simple graphical test. BMJ. 1997;315629- 634
Link to Article
McAuley  LPham  BTugwell  PMoher  D Does the inclusion of grey literature influence estimates of intervention effectiveness reported in meta-analyses? Lancet. 2000;3561228- 1231
Link to Article
Evers  JLH Publication bias in reproductive research. Hum Reprod. 2000;152063- 2066
Link to Article
Kiroff  GK Publication bias in presentations to annual scientific congress. ANZ J Surg. 2001;71167- 171
Link to Article
Jadad  ARMoore  RACarrol  D  et al.  Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;171- 12
Link to Article
Schulz  KFChalmers  IHayes  RJAltman  DG Empirical evidence of bias. JAMA. 1995;273408- 412
Link to Article
Hasselblad  VHedges  LV Meta-analysis of screening and diagnostic tests. Psychol Bull. 1995;117167- 178
Link to Article
Begg  CBMazumdar  M Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;501088- 1101
Link to Article
Dickersin  KMin  Y-IMeinert  CL Factors influencing publication of research results. JAMA. 1992;267374- 378
Link to Article
Easterbrook  PJBerlin  JAGobalan  RMatthews  DR Publication bias in clinical research. Lancet. 1991;337867- 872
Link to Article
Stern  JMSimes  RJ Publication bias: evidence of delayed publication in a cohort study of clinical research papers. BMJ. 1997;315640- 645
Link to Article
Scherer  RWDickersin  KLangenberg  P Full publication of results initially presented in abstracts: a meta-analysis. JAMA. 1994;272158- 162
Link to Article
Moher  D Clinical-trial registration: a call for its implementation in Canada. CMAJ. 1993;1491657- 1658
Horton  RSmith  R Time to register randomized trials. Lancet. 1999;3541138- 1139
Link to Article
Roberts  IHoey  J An amnesty for unpublished trials [editorial]. CMAJ. 1997;1571548
Roberts  I An amnesty for unpublished trials: one year on, many trials are unregistered and the amnesty remains open [editorial]. BMJ. 1998;317763- 764
Link to Article
Sutton  AJDuval  SJTweedie  RLAbrams  KRJones  DR Empirical assessment of effect of publication bias on meta-analyses. BMJ. 2000;3201574- 1577
Link to Article
Sterne  JACGavaghan  DEgger  M Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol. 2000;531119- 1129
Link to Article
Macaskill  PWalter  SDIrwig  L A comparison of methods to detect publication bias in meta-analysis. Stat Med. 2001;20641- 654
Link to Article
Cook  DJGuyatt  GHRyan  G Should unpublished data be included in meta-analyses? JAMA. 1993;2692749- 2753
Link to Article
Moher  DPham  BJones  A  et al.  Does the quality of report of randomized trials affect estimates of intervention efficacy reported in meta-analyses? Lancet. 1998;352609- 613
Link to Article
Moher  DJones  ALepage  Lfor the CONSORT Group, Use of the CONSORT statement and quality of reports of randomized trials: a comparative before-and-after evaluation. JAMA. 2001;2851992- 1995
Link to Article
Sterling  TD Publication decisions and their possible effects on inferences drawn from tests of significance—or vice versa. J Am Stat Assoc. 1959;5430- 34

Figures

Place holder to copy figure label and caption
Figure 1.

Time to publication by significant and nonsignificant findings.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Funnel plot of published studies. Outliers: −9.4, 25; −5.1, 14; −1.4, 6794; −0.6, 2342; −0.2, 5699; and 0.1, 2416.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Funnel plot of all studies. Outliers: −9.4, 25; −5.1, 14; −1.4, 6794; −0.6, 2342; −0.2, 5699; 0.1, 2416; and 10.8, 7.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Abstracts Published in Manuscript Form, by Year*
Table Graphic Jump LocationTable 2. Quality Variables by Document Type*
Table Graphic Jump LocationTable 3. Predictors of Publication: Univariate Results*
Table Graphic Jump LocationTable 4. Predictors of Publication: Results From Logistic Regression (n = 343)*

References

Simes  RJ Publication bias: the case for an international registry of clinical trials. J Clin Oncol. 1986;41529- 1541
Ausejo  MSaenz  APham  B  et al.  The effectiveness of glucocorticoids in treating croup. BMJ. 1999;319595- 600
Link to Article
Egger  MSmith  GDSchneider  MMinder  C Bias in meta-analysis detected by a simple graphical test. BMJ. 1997;315629- 634
Link to Article
McAuley  LPham  BTugwell  PMoher  D Does the inclusion of grey literature influence estimates of intervention effectiveness reported in meta-analyses? Lancet. 2000;3561228- 1231
Link to Article
Evers  JLH Publication bias in reproductive research. Hum Reprod. 2000;152063- 2066
Link to Article
Kiroff  GK Publication bias in presentations to annual scientific congress. ANZ J Surg. 2001;71167- 171
Link to Article
Jadad  ARMoore  RACarrol  D  et al.  Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;171- 12
Link to Article
Schulz  KFChalmers  IHayes  RJAltman  DG Empirical evidence of bias. JAMA. 1995;273408- 412
Link to Article
Hasselblad  VHedges  LV Meta-analysis of screening and diagnostic tests. Psychol Bull. 1995;117167- 178
Link to Article
Begg  CBMazumdar  M Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;501088- 1101
Link to Article
Dickersin  KMin  Y-IMeinert  CL Factors influencing publication of research results. JAMA. 1992;267374- 378
Link to Article
Easterbrook  PJBerlin  JAGobalan  RMatthews  DR Publication bias in clinical research. Lancet. 1991;337867- 872
Link to Article
Stern  JMSimes  RJ Publication bias: evidence of delayed publication in a cohort study of clinical research papers. BMJ. 1997;315640- 645
Link to Article
Scherer  RWDickersin  KLangenberg  P Full publication of results initially presented in abstracts: a meta-analysis. JAMA. 1994;272158- 162
Link to Article
Moher  D Clinical-trial registration: a call for its implementation in Canada. CMAJ. 1993;1491657- 1658
Horton  RSmith  R Time to register randomized trials. Lancet. 1999;3541138- 1139
Link to Article
Roberts  IHoey  J An amnesty for unpublished trials [editorial]. CMAJ. 1997;1571548
Roberts  I An amnesty for unpublished trials: one year on, many trials are unregistered and the amnesty remains open [editorial]. BMJ. 1998;317763- 764
Link to Article
Sutton  AJDuval  SJTweedie  RLAbrams  KRJones  DR Empirical assessment of effect of publication bias on meta-analyses. BMJ. 2000;3201574- 1577
Link to Article
Sterne  JACGavaghan  DEgger  M Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol. 2000;531119- 1129
Link to Article
Macaskill  PWalter  SDIrwig  L A comparison of methods to detect publication bias in meta-analysis. Stat Med. 2001;20641- 654
Link to Article
Cook  DJGuyatt  GHRyan  G Should unpublished data be included in meta-analyses? JAMA. 1993;2692749- 2753
Link to Article
Moher  DPham  BJones  A  et al.  Does the quality of report of randomized trials affect estimates of intervention efficacy reported in meta-analyses? Lancet. 1998;352609- 613
Link to Article
Moher  DJones  ALepage  Lfor the CONSORT Group, Use of the CONSORT statement and quality of reports of randomized trials: a comparative before-and-after evaluation. JAMA. 2001;2851992- 1995
Link to Article
Sterling  TD Publication decisions and their possible effects on inferences drawn from tests of significance—or vice versa. J Am Stat Assoc. 1959;5430- 34

Correspondence

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