Accepted for Publication: July 6, 2014.
Published Online: October 6, 2014. doi:10.1001/jamapediatrics.2014.1560.
Study concept and design: Persaud, Patel, Siberry, Van Dyke, Seage, Luzuriaga.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Persaud, Patel, Rainwater-Lovett, Chen, Luzuriaga.
Critical revision of the manuscript for important intellectual content: Persaud, Patel, Karalius, Rainwater-Lovett, Ziemniak, Ellis, Richman, Siberry, Van Dyke, Burchett, Seage, Luzuriaga.
Statistical analysis: Patel, Karalius, Rainwater-Lovett, Seage.
Obtained funding: Persaud, Van Dyke, Seage, Luzuriaga.
Administrative, technical, or material support: Persaud, Rainwater-Lovett, Ziemniak, Ellis, Chen, Siberry, Van Dyke, Seage, Luzuriaga.
Study supervision: Persaud, Ziemniak, Siberry, Van Dyke, Burchett, Seage, Luzuriaga.
Conflict of Interest Disclosures: Dr Richman has consulted for Chimerix, BMS, Gilead, Gen-Probe, Monogram, Sirenas, and Prism. No other disclosures were reported.
Funding/Support: The laboratory studies were supported by grants R01HD080474 and R21AI100656 from the National Institutes of Health (NIH) (Dr Persaud); by funding from the American Foundation for AIDS Research (Drs Persaud and Luzuriaga); and by grants UO1-AI-068632 from the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (Dr Persaud) and P30-AI094189 from the Johns Hopkins University Center for AIDS Research (Dr Persaud). The study was also supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development with cofunding from the National Institute on Drug Abuse, the National Institute of Allergy and Infectious Diseases, the Office of AIDS Research, the National Institute of Mental Health, the National Institute of Neurological and Communicative Disorders and Stroke, the National Institute on Deafness and Other Communication Disorders, the National Heart, Lung, and Blood Institute, the National Institute of Dental and Craniofacial Research, and the National Institute on Alcohol Abuse and Alcoholism through cooperative agreements HD052102, 3 U01 HD052102-05S1, and 3 U01 HD052102-06S3 with the Harvard School of Public Health (principal investigator [PI], George R. Seage III, DSc, MPH; project director, Julie Alperen, DrPH) and HD052104 and 3U01 HD052104-06S1 from the Tulane University School of Medicine (PI, Russell B. Van Dyke, MD; co-PI, Kenneth Rich, MD; project director, Patrick Davis, BS). Dr Richman was supported by grant U19 AI096113 from the Collaboratory for AIDS Research on Eradication (CARE), grant AI306214 from the University of California, San Diego, Center for AIDS Research, and the James Pendleton Charitable Trust. Data management services were provided by Frontier Science and Technology Research Foundation (PI, Suzanne Siminski, MS, MBA), and regulatory services and logistical support were provided by Westat, Inc (PI, Julie Davidson, MSN).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Group Information: The following institutions, clinical site investigators, and staff participated in conducting the Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol in 2012: William Shearer, MD, PhD, Mary Paul, MD, Norma Cooper, MA, and Lynnette Harris, PhD (Baylor College of Medicine, Houston, Texas); Murli Purswani, MD, Mahboobullah Baig, MBBS, and Anna Cintron, MS (Bronx Lebanon Hospital Center, Bronx, New York); Ana Puga, MD, Sandra Navarro, BA, Doyle Patton, PhD, and Dayana Leon, LPN (Children’s Diagnostic and Treatment Center, Ft Lauderdale, Florida); Sandra Burchett, MD, Nancy Karthas, NP, and Betsy Kammerer, PhD (Boston Children’s Hospital, Boston, Massachusetts); Ram Yogev, MD, Margaret Ann Sanders, MPH, Kathleen Malee, PhD, and Scott Hunter, PhD (Ann and Robert H. Lurie Children’s Hospital, Chicago, Illinois); Andrew Wiznia, MD, Marlene Burey, RN, and Molly Nozyce, PhD (Jacobi Medical Center, Bronx, New York); Janet Chen, MD, Latreca Ivey, MPH, Maria Garcia Bulkley, PA-C, and Mitzie Grant, PhD (St Christopher’s Hospital for Children, Philadelphia, Pennsylvania); Katherine Knapp, MD, Kim Allison, BSN, and Megan Wilkins, PhD (St Jude Children’s Research Hospital, Memphis, Tennessee); Midnela Acevedo-Flores, MD, Heida Rios, MS, and Vivian Olivera, PhD (Department of Pediatrics, San Juan Hospital, San Juan, Puerto Rico); Margarita Silio, MD, Medea Jones, RN, and Patricia Sirois, PhD (Tulane University Health Sciences Center, New Orleans, Louisiana); Stephen Spector, MD, Kim Norris, RN, BSN, and Sharon Nichols, PhD (University of California, San Diego, La Jolla); Elizabeth McFarland, MD, Emily Barr, CPNP-PC, and Robin McEvoy, PhD (University of Colorado Denver Health Sciences Center); Arry Dieudonne, MD, Linda Bettica, RN, and Susan Adubato, PhD (University of Medicine and Dentistry of New Jersey, Newark); and Gwendolyn Scott, MD, Patricia Bryan, BSN, MPH, and Elizabeth Willen, PhD (University of Miami, Miami, Florida).
Disclaimer: The conclusions and opinions expressed in this article are those of the authors and do not necessarily reflect those of the NIH or the US Department of Health and Human Services.
Additional Contributions: We thank the children and families for their participation in the PHACS and the individuals and institutions involved in the conduct of the PHACS. Linda Lambrecht, MS, and Margaret McManus, BS, University of Massachusetts, Worchester, contributed to the human immunodeficiency virus serologic testing, and Matt Strain, MD, PhD, and Steven Lada, BS, from the University of California, San Diego, La Jolla, provided advice and support on proviral DNA quantitation. None of these individuals received financial compensation.
Correction: This article was corrected on December 1, 2014, to fix the Funding/Support section.