0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Special Feature |

Pathological Case of the Month FREE

Atilano Lacson, MD; Kenneth Washington, MD; Gerald Tuite, MD; Robert Nuttall, MD
[+] Author Affiliations

Section Editor: Enid Gilbert-barness, MD


Arch Pediatr Adolesc Med. 2001;155(7):851-852. doi:10.1001/archpedi.155.7.851.
Text Size: A A A
Published online

A PREVIOUSLY healthy 6-year-old boy received lamotrigine after examination for seizures involving the left face and arms. Cranial computed tomography showed a probable brain tumor. Surgery was deferred because of family relocation. On examination 3 months later, he was awake, alert, and had no focal neurological signs. A repeated magnetic resonance imaging study revealed a densely enhancing focal lesion in the right parietal region with mild edema of the underlying white matter (Figure 1). Additionally, he had mild maxillary and ethmoid sinus disease. He underwent a right frontal craniotomy under Stealth guidance. The lesion was partly adherent to the overlying dura mater and was within a portion of the premotor cortex, which was excised. The entire lesion was resected. Biopsy findings revealed a lesion that was well-demarcated from the surrounding brain and consisted of islands and broad zones of reactive, granulation tissue–like whorls of fibrocapillary proliferation with a diffuse infiltrate of lymphocytes, plasma cells, and histiocytes (Figure 2). Plasma cells and histiocytes dominate the inflammatory components. The lesion contained many lipid-rich histiocytes, collagen, and cells that express HLA-DR, CD20, and CD68 (Figure 3). The patient was discharged after surgery with mild residual facial weakness. At last follow-up, he was seizure free.

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 3

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
JAMAevidence.com