Desmoplastic cerebral astrocytoma of infancy6- 8 is a superficially situated, supratentorial glioma. Grossly, the lesion appears as a large, firm, globular mass, densely adherent to the surface of the brain. A distinctive feature is the intense desmoplasia that imparts a fibrotic appearance. Scattered elongated glial cells, strongly positive for glial fibrillary acid protein, are seen. No ganglion cells are seen. Desmoplastic infantile ganglioglioma9,10 are supratentorial, superficially situated cystic tumors. Microscopically they show collagenous rich tissue of varying cellularity with an appearance of a neurofibroma. Ganglion cells are plump, small to medium sized, and mixed with glial cells or isolated within the desmoplastic tissue. The neuronal nature of these cells is suggested by their roundness, vesicular nuclei, variably prominent nucleoli, and Nissl substance. The spindle cells are strongly positive for glial fibrillary acid protein.