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The Pediatric Forum |

Neurological Diagnosis on a Reported Case of Chromosome 10 qter Deletion—Reply

Dennis T. Costakos, MD
Arch Pediatr Adolesc Med. 1998;152(11):1155. doi:.
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Thank you for your inquiry about our recent case report,1 regarding the literature of 10 qter deletion and brain abnormalities as diagnosed by cranial ultrasonogram, cranial computed tomographic scan, or magnetic resonance imaging. Cerebral nervous system abnormalities by imaging is reported in 20% of the published case reports of patients with 10 qter deletion syndrome.

In a report of 3 cases of 10 qter deletion syndrome by Wulfsberg et al,2 they reported that in patients they tested patient 1 had a normal cranial ultrasonogram and patient 3 had a normal computed tomographic scan. Wulfsberg et al cite an article by Wegener et al,3 in which one patient with 10 qter deletion syndrome has agenesis of the corpus callosum. Teyssier et al4 report a case in which the cerebral scan is normal. Wilkie et al5 report 2 cases, with patient 1 having a normal cranial computed tomographic scan and patient 2 having a normal cranial ultrasonogram. Kogasaka et al report that for one patient "at 7 months brain CT scan showed a mildly atrophic lesion in the frontal lobes and a mildly enlarged ventricle."6

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