We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

It Is Too Early to Declare Early or Late Rescue High-Frequency Oscillatory Ventilation Dead—Reply

Punkaj Gupta, MBBS1,2; Robert M. Kacmarek, PhD, RRT3; Randall C. Wetzel, MBBS4
[+] Author Affiliations
1Division of Pediatric Critical Care, University of Arkansas Medical Center, Little Rock
2Division of Pediatric Cardiology, University of Arkansas Medical Center, Little Rock
3Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston
4Department of Anesthesiology and Critical Care Medicine, Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles
JAMA Pediatr. 2014;168(9):863. doi:10.1001/jamapediatrics.2014.934.
Text Size: A A A
Published online


In Reply We appreciate the insightful comments by Kneyber et al, Essouri et al, and Rimensberger et al concerning our article in JAMA Pediatrics comparing the outcomes associated with the use of high-frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation in children with acute respiratory failure.1 We agree with the limitations of database studies. Owing to the nature of the database used for this study, we lacked important parameters such as peak inspiratory pressure, positive end-expiratory pressure, partial pressure of oxygen and carbon dioxide in arterial blood, fraction of inspired oxygen, the alveolar-arterial difference in partial pressure of oxygen and fraction of inspired oxygen ratio, presence of focal vs diffuse lung disease, use of nitric oxide, and presence of air leak.1 These were explicitly mentioned in the limitations section of the article. However, we were able to match many important severity of illness variables such as the Pediatric Index of Morality 2 score and Pediatric Risk of Mortality 3 score, arterial catheter use, central venous access, use of hemodialysis catheter, use of extracorporeal membrane oxygenation, cardiopulmonary resuscitation or defibrillation use, a variety of diagnoses, and patient vitals including heart rate and blood pressure.1


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





September 1, 2014
Sandrine Essouri, MD, PhD; Guilllaume Emeriaud, MD, PhD; Philippe Jouvet, MD, PhD
1Pediatric Intensive Care Unit, Centre Hospitalier Universitaire Sainte-Justine, Chemin de la Côte Sainte Catherine, Montréal, Québec, Canada
JAMA Pediatr. 2014;168(9):861-862. doi:10.1001/jamapediatrics.2014.937.
September 1, 2014
Peter C. Rimensberger, MD; Thomas E. Bachman, MSHA
1Service of Neonatology and Pediatric Intensive Care, Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland
2Mountains Community Hospital, Lake Arrowhead, California
JAMA Pediatr. 2014;168(9):862-863. doi:10.1001/jamapediatrics.2014.940.
September 1, 2014
Martin C. J. Kneyber, MD, PhD; Marc van Heerde, MD, PhD; Dick G. Markhorst, MD, PhD
1Division of Pediatric Intensive Care, Department of Pediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands2Critical Care, Anesthesiology, Perioperative Medicine, and Emergency Medicine (CAPE), University of Groningen, Groningen, the Netherlands
3Division of Pediatric Intensive Care, Department of Pediatrics, VU University Medical Center, Amsterdam, the Netherlands
JAMA Pediatr. 2014;168(9):861. doi:10.1001/jamapediatrics.2014.961.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...