Accepted for Publication: April 17, 2014.
Published Online: August 11, 2014. doi:10.1001/jamapediatrics.2014.900.
Study concept and design: Tozzi.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Shashaj, Manco.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, or material support: Graziani, DiCorpo, Morano, Tacconi, and Veronelli.
Conflict of Interest Disclosures: Dr Manco reported receiving additional funds from the Italian Ministry of Health (grant GR-2010 2304957) and from the European Community (grants FP7-ICT-2012-600932 MD PAEDIGREE and FP7-ICT-2012-610440 DAPHNE). No other disclosures were reported.
Funding/Support: The work was supported by grant RF-OPG-2008-1142374 from the Italian Ministry of Health (Dr Manco).
Role of the Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: The following family pediatricians from Federazione Italiana Medici Pediatri, Rome, Italy, contributed to patient enrollment: Cristina Ciuffo, MD, Claudia Cives, MD, Sandra Facciolini, MD, Paola Giammaria, MD, Patrizia Iorio Gnisci, MD, Maria Cristina Loreti, MD, Antonella Nicolosi, MD, Giuseppe Oliviero, MD, Carmelo Rachele, MD, Maria Luisa Rigoni, MD, Tiziana Sisti, MD, Stefania Spaterna, MD, Marco Taloni, MD, Mauro Taucci, MD, and Maria Teresa Zucco. Daniele Pastori, MD, Lodovica Perri, MD, and Valerio Sanguigni, MD, at Fondazione Livio Patrizi, Rome, Italy, and Giulia Cafiero, MD, at Bambino Gesù Children’s Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy, performed ultrasonographic analyses. Rino Moraglia (Fimesan Spa, Bari, Italy), Luigi Cantarurri (SoSePe Srl, Padova, Italy), and Francesco Sposaro (Reply Spa, Roma, Italy) provided technical support.