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Special Feature |

Radiological Case of the Month FREE

[+] Author Affiliations

Section Editor: Beverly P. Wood, MD

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Arch Pediatr Adolesc Med. 1998;152(1):88. doi:.
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Published online

DENOUEMENT AND DISCUSSION: GRANULOMATOUS HEPATITIS IN CAT-SCRATCH DISEASE

Figure 1. A spiral computed tomographic scan of the abdomen shows 4 well-defined, hypodense, hepatic lesions (arrows) with peripheral contrast enhancement. There is also a large area of low attentuation in the posterior segment of the right lobe of the liver.

Figure 2. The single photon emission computed tomographic technetium Tc 99m sulfur colloid liver-spleen scan shows inhomogeneous uptake of tracer in the right lobe with focal areas (arrowheads) of absent tracer uptake corresponding to the spiral computed tomographic abnormalities.

Cat-scratch disease (CSD) is caused by an argyrophilic, gram-negative, pleomorphic bacillus known as Bartonella (Rochalimaea) henselae. The diagnosis is made when 3 of the 4 following criteria are satisfied: (1) history of cat contact, associated with skin or eye inoculation, (2) positive CSD skin test, (3) normal laboratory study findings for other causes of lymphadenopathy, and (4) characteristic histopathologic features in the biopsy specimen of the involved skin or lymph node.1

The disease typically presents a fever and regional lymphadenopathy located adjacent to the inoculated site within 2 weeks after exposure to the cat. The cat is usually less than 1 year of age. The inoculated site appears as a papule 3 to 5 days after exposure and becomes vesicular and crusty. The involved lymph nodes may remain enlarged for months. Axillary lymphadenopathy is common because the hands and arms are the usual sites of inoculation. Other sites include the cervical and the inguinal regions. The histopathologic feature of the involved lymph node is a granuloma with central necrosis, infiltrating neutrophils, and lymphoid hyperplasia. The course of the disease is self-limited and seldom needs medical therapy. About 10% to 12% of the patients have unusual presentations making the diagnosis less obvious.2 Granulomatous hepatitis presenting with fever and abdominal pain, with or without lymphadenopathy, has been reported in the past.3,4 Rare presentations of CSD include Parinaud oculoglandular syndrome, acute encephalopathy,5 osteolytic lesions,6 transverse myelitis,7 neuroretinitis, aseptic meningitis,8 thrombocytopenic purpura, atypical pneumonia, and erythema nodosum.2 Gastrointestinal manifestations of CSD may include granulomatous splenitis and appendicitis.9 Atypical presentations may mimic other serious illnesses, such as lymphoma, tuberculosis, and malignancies. If the diagnosis of CSD is not considered early on, unnecessary, extensive and costly workup may ensue.

Of particular interest in this case is the extensive radiologic workup of the suspicious hepatic hypoechoic lesions found on the ultrasound film. With the findings of the computed tomographic, liver-spleen, and tagged red blood cell scans, we were able to rule out cystic lesions, benign nodular hyperplasia and hemangioma, respectively. Hepatocellular adenoma was considered as a possibility due to the detection of multiple cold defects on the liver-spleen scan. An open liver biopsy was performed. Operative findings revealed multiple nodules and histology showed necrotizing granulomas with special staining suspicious for CSD. The liver tissue was positive by DNA polymerase chain reaction for B henselae. Enzyme-linked immunosorbent assay serologies for B henselae were also positive.

The disease is self-limiting and seldom needs antibiotic therapy. However, in some cases of extensive lymphadenopathy and liver-spleen involvement, intravenous gentamicin has been used with success.10,11 In another study, ciprofloxacin has been shown to be an effective therapy for CSD.12

Accepted for publication December 16, 1996.

Reprints: Theodore Hall, MD, Radiological Science BL-428, CHS, 10833 Le Conte Ave, Los Angeles, CA 90095.

Schartzman  WA Infections due to Rochalimaea: the expanding clinical spectrum. Clin Infect Dis. 1992;15893- 902
Link to Article
Margileth  MAWear  DJEnglish  CK Systemic cat-scratch disease: report of 23 patients with prolonged or recurrent severe bacterial infection. J Infect Dis. 1987;155390- 402
Link to Article
Malatack  JJJaffe  R Granulomatous hepatitis in three children due to cat-scratch disease without peripheral adenopathy. AJDC. 1993;147949- 953
Dangman  BCAlbanese  BAKacica  MALepow  MLWallach  MT Cat-scratch disease in two children presenting with fever of unknown origin: imaging features and association with a new causative agent, Rochalimaea henselae. Pediatrics. 1995;5767- 771
Noah  DLBresee  JSGorenselc  Not Available  et al.  Cluster of five children with acute encephalopathy associated with cat-scratch disease in South Florida. Pediatr Infect Dis J. 1995;14866- 869
Link to Article
Carithers  HA Cat-scratch disease: an overview based on a study of 1,200 patients. AJDC. 1985;1391124- 1133
Pickerill  RGMilder  JE Transverse myelitis associated with cat-scratch disease in an adult. JAMA. 1981;2462840- 2841
Link to Article
Wong  MTDolan  MJLattuada  CP  et al.  Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella henselae infection in immunocompetent patients and patients infected with HIV type 1. Clin Infect Dis. 1995;21352- 360
Link to Article
Delahoussaye  PMOsborne  BM Cat-scratch disease presenting as abdominal visceral granulomas. J Infect Dis. 1990;16171- 78
Link to Article
Bogue  CWWise  JDGray  GFEdwards  KM Antibiotic therapy for cat-scratch disease? JAMA. 1989;262813- 816
Link to Article
Musso  DDrancourt  MRaoult  D Lack of bactericidal effect of antibiotics except aminoglycosides on Bartonella henselae. J of Antimicrob Chemother. 1994;36101- 108
Link to Article
Holley  P  Jr Successful treatment of cat-scratch disease with ciprofloxacin. JAMA. 1991;2651563- 1565
Link to Article

Tables

References

Schartzman  WA Infections due to Rochalimaea: the expanding clinical spectrum. Clin Infect Dis. 1992;15893- 902
Link to Article
Margileth  MAWear  DJEnglish  CK Systemic cat-scratch disease: report of 23 patients with prolonged or recurrent severe bacterial infection. J Infect Dis. 1987;155390- 402
Link to Article
Malatack  JJJaffe  R Granulomatous hepatitis in three children due to cat-scratch disease without peripheral adenopathy. AJDC. 1993;147949- 953
Dangman  BCAlbanese  BAKacica  MALepow  MLWallach  MT Cat-scratch disease in two children presenting with fever of unknown origin: imaging features and association with a new causative agent, Rochalimaea henselae. Pediatrics. 1995;5767- 771
Noah  DLBresee  JSGorenselc  Not Available  et al.  Cluster of five children with acute encephalopathy associated with cat-scratch disease in South Florida. Pediatr Infect Dis J. 1995;14866- 869
Link to Article
Carithers  HA Cat-scratch disease: an overview based on a study of 1,200 patients. AJDC. 1985;1391124- 1133
Pickerill  RGMilder  JE Transverse myelitis associated with cat-scratch disease in an adult. JAMA. 1981;2462840- 2841
Link to Article
Wong  MTDolan  MJLattuada  CP  et al.  Neuroretinitis, aseptic meningitis, and lymphadenitis associated with Bartonella henselae infection in immunocompetent patients and patients infected with HIV type 1. Clin Infect Dis. 1995;21352- 360
Link to Article
Delahoussaye  PMOsborne  BM Cat-scratch disease presenting as abdominal visceral granulomas. J Infect Dis. 1990;16171- 78
Link to Article
Bogue  CWWise  JDGray  GFEdwards  KM Antibiotic therapy for cat-scratch disease? JAMA. 1989;262813- 816
Link to Article
Musso  DDrancourt  MRaoult  D Lack of bactericidal effect of antibiotics except aminoglycosides on Bartonella henselae. J of Antimicrob Chemother. 1994;36101- 108
Link to Article
Holley  P  Jr Successful treatment of cat-scratch disease with ciprofloxacin. JAMA. 1991;2651563- 1565
Link to Article

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