0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

Prophylactic Use of a Probiotic in the Prevention of Colic, Regurgitation, and Functional Constipation—Reply

Flavia Indrio, MD1; Antonio Di Mauro, MD1; Giuseppe Riezzo, MD2
[+] Author Affiliations
1Department of Pediatrics, Aldo Moro University of Bari, Bari, Italy
2Laboratory of Experimental Physiopathology, National Institute for Digestive Diseases, I.R.C.C.S. Saverio de Bellis, Castellana Grotte, Italy
JAMA Pediatr. 2014;168(8):778. doi:10.1001/jamapediatrics.2014.368.
Text Size: A A A
Published online

Extract

In Reply We thank Dr Sanaie and colleagues for their interest in our article.1 Dr Sanaie argues we used a nonmentioned oil as placebo that could have changed the gut behavior and enhanced or decreased the frequency of infantile colic, regurgitation, and functional constipation. However, we adopted a mentioned pharmaceutical oily suspension of sunflower and medium-chain triglyceride oil containing probiotic bacteria in the intervention group and an equal oily suspension without probiotic bacteria in the placebo group. The only difference in oil between the groups was the presence of live bacteria. It is likely that probiotic supplementation had the majority of functional gastrointestinal disorders because the same oil was used for the 2 different formulations. We agree with Dr Sanaie about maternal diet as an influential factor associated with colic crying2 and no intervention on maternal diet had been done during our probiotic supplementation in breast-fed infants. However, our study included both breast-fed and formula-fed infants and no statistical differences were found in results comparing these subpopulations in infants supplemented with probiotic bacteria. Finally, Dr Sanaie is doubtful of the accuracy and validity of the information provided by parents because these aspects may be too subjective and were not reported daily in a medical record by a physician. The diagnosis of the disorders was always performed by an expert pediatric gastroenterologist following the Rome III criteria.3 In this approach, the subjective evaluation of symptoms by parent or caretaker is fundamental in physicians’ clinical practice, depending on reports and interpretations of the parents. The use of a diary recorded by parents has been used in several previous studies.4,5 Moreover, a recent article by Sung et al6 indicates clinical diaries reviewed by an expert pediatrician is a reliable method in clinical trial protocol for infantile colic.

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

August 1, 2014
Sarvin Sanaie, MD, PhD; Ata Mahmoodpoor, MD; Samad E. J. Golzari, MD
1Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
2Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
JAMA Pediatr. 2014;168(8):777-778. doi:10.1001/jamapediatrics.2014.365.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

522 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();