Accepted for Publication: February 5, 2014.
Published Online: June 23, 2014. doi:10.1001/jamapediatrics.2014.296.
Study concept and design: Virtanen, Takkinen, Nwaru, Kaila, Nevalainen, Simell, Hyöty, Veijola, Knip.
Acquisition, analysis, or interpretation of data: Virtanen, Takkinen, Nwaru, Kaila, Ahonen, Nevalainen, Niinistö, Siljander, Simell, Hyöty, Veijola, Knip.
Drafting of the manuscript: Virtanen, Takkinen, Nwaru, Nevalainen.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Takkinen, Nwaru, Nevalainen.
Obtained funding: Virtanen, Simell, Hyöty, Veijola, Knip.
Administrative, technical, or material support: Virtanen, Kaila, Ahonen, Siljander, Simell, Ilonen, Veijola, Knip.
Study supervision: Virtanen, Nevalainen, Veijola, Knip.
Conflict of Interest Disclosures: None reported.
Funding/Support: The study was supported by the Academy of Finland (grants 44105, 48724, 80846, 201988, 126813, and 129492, and Centre of Excellence in Molecular Systems Immunology and Physiology Research 2012-17 grant 250114); the Prevaller Consortium; the European Foundation for the Study of Diabetes (EFSD/Novo Nordisk Partnership and ESFD/Juvenile Diabetes Research Foundation/Novo Nordisk Programme); the Foundation for Pediatric Research; the Tampere Tuberculosis Foundation; the Juho Vainio Foundation; the Yrjö Jahnsson Foundation; Medical Research Funds, Turku University Hospital and Oulu University Hospital; the Juvenile Diabetes Research Foundation; Novo Nordisk Foundation; EU Biomed 2 Program (grant BMH4-CT98-3314); and the Competitive Research Funding of the Tampere University Hospital (grants 9B099, 9C084, 9D081, 9E082, 9F089, 9G087, 9H092, 9J147, 9K149, 9L117, 9M114, 9N086, and 9P057).
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the physicians, research nurses, nutritionists, and laboratory staff of the Type 1 Diabetes Prediction and Prevention Study for their continuous collaboration through the years. We express our gratitude to Eeva Korhonen (Tampere University Hospital), Sirpa Pohjola (Oulu University Hospital), and Katri Jokinen, MSc (University of Tampere), for their expert technical assistance. The contributors did not receive financial compensation.