Managing CFS is complex for several reasons. First, there is no cure for CFS. Second, symptoms can be a little different for every patient, and for any patient the symptoms can get better or worse over time. Patients and families should be careful in adopting therapies or medicines that companies or health care providers claim are able to cure CFS, because there is no known cure at this time. However, certain therapies such as cognitive behavioral therapy (also called CBT) and graded exercise therapy have been found to significantly reduce fatigue. Many patients with CFS also have depression, which can be successfully treated with therapy and medication. Researchers are seeking new medical treatments for CFS.