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Parathyroid Hormone as a Functional Indicator of Vitamin D Sufficiency in Children

Jonathon L. Maguire, MD, MSc, FRCPC1; Catherine Birken, MD, MSc, FRCPC2; Kevin E. Thorpe, MMath1; Etienne B. Sochett, MBBCH3; Patricia C. Parkin, MD, FRCPC2
[+] Author Affiliations
1Li Ka Shing Knowledge Institute of St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada
2Pediatrics Outcomes Research Team, Division of Paediatric Medicine, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
3Division of Pediatric Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada
JAMA Pediatr. 2014;168(4):383-385. doi:10.1001/jamapediatrics.2013.5379.
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There has been debate on what constitutes physiologically normal 25-hydroxyvitamin D serum levels in children. The Institute of Medicine and the American Academy of Pediatrics have recommended that 25-hydroxyvitamin D levels in children be more than 50 nmol/L.1 The Canadian Paediatric Society has suggested that 25-hydroxyvitamin D levels be more than 75 nmol/L.2 Given the long time course for the development of chronic health outcomes that may be related to low vitamin D levels in children, physiological indicators of vitamin D sufficiency would be helpful.

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Plot of the Regression Model for 25-Hydroxyvitamin D and Parathyroid Hormone (PTH)

Shaded areas inside the dashed lines represent 95% confidence intervals.

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