Accepted for Publication: October 9, 2013.
Published Online: February 3, 2014. doi:10.1001/jamapediatrics.2013.4647.
Study concept and design: Sulheim, Fagermoen, Winger, Godang, Rowe, Saul, Øie, Wyller.
Acquisition of data: Sulheim, Fagermoen, Winger, Andersen.
Analysis and interpretation of data: Sulheim, Fagermoen, Godang, Müller, Rowe, Saul, Skovlund, Øie, Wyller.
Drafting of the manuscript: Sulheim, Fagermoen, Godang.
Critical revision of the manuscript for important intellectual content: Fagermoen, Winger, Andersen, Müller, Rowe, Saul, Skovlund, Øie, Wyller.
Statistical analysis: Sulheim, Fagermoen, Skovlund, Wyller.
Obtained funding: Winger, Wyller.
Administrative, technical, or material support: Winger, Andersen Godang, Müller, Saul, Wyller.
Study supervision: Godang, Müller, Skovlund, Øie, Wyller.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was funded by Health South–East Hospital Trust, the University of Oslo, Oslo and Akershus University College of Applied Sciences, the Norwegian Competence Network of Paediatric Pharmacotherapy, Simon Fougner Hartmann’s Family Foundation, and Eckbo’s Family Foundation.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Kari Gjersum provided secretarial assistance; Hamsana Chandrakumar, BSc, Reidar Due, MD, Esther Gangsø, BSc, Anne Marie Halstensen, RN, Adelheid Holm, RN, Berit Widerøe Njølstad, MA, Pelle Rohdin, RN, Anna Marie Thorendal Ryenbakken, Marianne Svendsen, BSc, and Kristin Villa, RN, provided practical assistance; Jan Peder Amlie, MD, PhD, Pål Aukrust, MD, PhD, Stein Bergan, MD, PhD, Jens Bollerslev, MD, PhD, Michael Bretthauer, MD, PhD, Hege Christensen, MD, PhD, Mirjam Ekstedt, MA, PhD, Tor Endestad, MA, PhD, Johan Arild Evang, MD, PhD, Johannes Gjerstad, MSc, PhD, Helene Gjone, MD, PhD, Ingrid B. Helland, MD, PhD, Sølvi Helseth, MA, PhD, Harald Hurum, MD, Ulf Geir Indahl, MSc, PhD, Olav Klingenberg, MD, PhD, Gunnvald Kvarstein, MD, PhD, Annika Melinder, MA, PhD, Halvor Rollag, MD, PhD, Erik Thaulow, MD, PhD, Kristin Tøndel, MSc, PhD, Thor Ueland, MD, PhD, and Nils Tore Vethe, MD, participated in discussions on study design and results; Terje Rootwelt, MD, PhD, and Øyvind Skraastad, MD, PhD, provided institutional support; Liv Thrane Bjerke, MSc, provided pharmacy services; Bjørn Bendz, MD, PhD, Gaute Døhlen, MD, PhD, Knut Engedal, MD, PhD, and Ola Didrik Saugstad, MD, PhD, contributed study monitoring; and Berit Bjelkåsen, MSc, developed the computerized randomization procedure. We thank all referring units and all participants and their parents and next of kin.