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Research Letter |

CD4 Counts of Nonperinatally HIV–Infected Youth and Young Adults Presenting for HIV Care Between 2002 and 2010

Allison L. Agwu, MD, ScM1,2; Asha Neptune, MA, MPH3; Cindy Voss, MA2; Baligh Yehia, MD, MPP, MSHP4; Richard Rutstein, MD5 ; for the HIV Research Network
[+] Author Affiliations
1Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland
2Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland
3Howard University College of Medicine, Washington, DC
4Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
5Division of General Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
JAMA Pediatr. 2014;168(4):381-383. doi:10.1001/jamapediatrics.2013.4531.
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Human immunodeficiency virus (HIV) incidence is increasing among youth, particularly young men who have sex with men and racial/ethnic minorities. Earlier presentation to care, a goal of public health initiatives, can limit immune deterioration and HIV transmission. We determined if fewer nonperinatally HIV (nPHIV)–infected youth are presenting for care at lower CD4 counts.

Article InformationCorresponding Author: Allison L. Agwu, MD, ScM, 200 N Wolfe St, Room 3145, Baltimore, MD 21287 (ageorg10@jhmi.edu).

Published Online: February 3, 2014. doi:10.1001/jamapediatrics.2013.4531.

Author Contributions: Dr Agwu had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Agwu, Yehia, Rutstein.

Acquisition of data: Voss.

Analysis and interpretation of data: Agwu, Neptune, Yehia.

Drafting of the manuscript: Agwu, Neptune, Voss.

Critical revision of the manuscript for important intellectual content: Agwu, Neptune, Yehia, Rutstein.

Statistical analysis: Agwu, Neptune.

Obtained funding: Agwu.

Administrative, technical, or material support: Voss, Yehia.

Study supervision: Agwu.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported by Agency for Healthcare Research and Quality grant 290-01-0012 and Health Resources and Services Administration contract HHSH250201200008C . Dr Agwu was supported by National Institutes of Allergy and Infectious Diseases grant 1K23 AI084549 and a Ross Clinician Scientist Award. Ms Neptune was supported by the James A. Ferguson Emerging Infectious Diseases Fellowship (5U50MN000025-02). Dr Yehia was supported by National Institutes of Health grant K23-MH-097647-01A1.

Role of the Sponsor: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Group Information: HIV Research Network participating sites and principal investigators: Alameda County Medical Center, Oakland, California: Howard Edelstein, MD; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania: Richard Rutstein, MD; Community Health Network, Rochester, New York: Roberto Corales, DO; Drexel University, Philadelphia, Pennsylvania: Jeffrey Jacobson, MD, Sara Allen, CRNP; Johns Hopkins University, Baltimore, Maryland: Kelly Gebo, MD, Richard Moore, MD, Allison Agwu, MD; Montefiore Medical Group, Bronx, New York: Robert Beil, MD; Montefiore Medical Center, Bronx, New York: Lawrence Hanau, MD; Oregon Health and Science University, Portland: P. Todd Korthuis, MD; Parkland Health and Hospital System, Dallas, Texas: Ank Nijhawan, MD, Muhammad Akbar, MD; St. Jude's Children's Hospital and University of Tennessee, Memphis: Aditya Gaur, MD; St. Luke's Roosevelt Hospital Center, New York, New York: Victoria Sharp, MD, Stephen Arpadi, MD; Tampa General Health Care, Tampa, Florida: Charurut Somboonwit, MD; University of California, San Diego: W. Christopher Mathews, MD; Wayne State University, Detroit, Michigan: Jonathan Cohn, MD. Sponsoring agencies: Agency for Healthcare Research and Quality, Rockville, Maryland: Fred Hellinger, PhD, John Fleishman, PhD, Irene Fraser, PhD; Health Resources and Services Administration, Rockville, Maryland: Robert Mills, PhD, Faye Malitz, MS. Data Coordinating Center: Johns Hopkins University: Richard Moore, MD, Jeanne Keruly, CRNP, Kelly Gebo, MD, Cindy Voss, MA.

Disclaimer: The views expressed in this article are those of the authors. No official endorsement by the Department of Health and Human Services, the National Institutes of Health, or the Agency for Healthcare Research and Quality is intended or should be inferred.

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