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Comment & Response |

Induction or Augmentation of Labor and Autism—Reply

Marie Lynn Miranda, PhD1,2; Rebecca Anthopolos, MA2; Simon G. Gregory, PhD3,4
[+] Author Affiliations
1Department of Pediatrics, University of Michigan, Ann Arbor
2Children’s Environmental Health Initiative, School of Natural Resources and Environment, University of Michigan, Ann Arbor
3Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina
4Duke Institute of Molecular Physiology, Duke University Medical Center, Durham, North Carolina
JAMA Pediatr. 2014;168(2):191-192. doi:10.1001/jamapediatrics.2013.4792.
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In Reply We recently published a study demonstrating an association between labor induction/augmentation and later diagnosis of autism.1 Letter writers expressed concern about overinterpretation of study findings that may inappropriately influence delivery room practice. In the article, the associated press release, and all media interviews, we relayed a very conservative message emphasizing the distinction between association and causation and clearly stated that the work did not call for any change in obstetric practice. The potential for overinterpretation of scientific research by the press and lay public should not preclude publication of thoughtful scientific investigation. Research is an iterative process. Initial studies highlight directions for future research, the body of evidence grows, and health drivers are clarified.

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February 1, 2014
Michael L. Stitely, MD
1Department of Women’s and Children’s Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
JAMA Pediatr. 2014;168(2):189-190. doi:10.1001/jamapediatrics.2013.4789.
February 1, 2014
Anthony M. Vintzileos, MD; Cande V. Ananth, PhD, MPH
1Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, New York
2Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York3Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York
JAMA Pediatr. 2014;168(2):190. doi:10.1001/jamapediatrics.2013.4795.
February 1, 2014
George R. Saade, MD; Baha M. Sibai, MD; Robert Silver, MD
1Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston
2Department of Obstetrics and Gynecology, University of Texas Health Sciences at Houston, Houston
3Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City
JAMA Pediatr. 2014;168(2):190-191. doi:10.1001/jamapediatrics.2013.4800.
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