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Comment & Response |

Questions Concerning Nasal Intermittent Positive-Pressure Ventilation vs Nasal Continuous Positive Airway Pressure—Reply

Jucille Meneses, MD, MS1; Vineet Bhandari, MD, DM2; Joao Guilherme Alves, MD1
[+] Author Affiliations
1Department of Pediatrics, Instituto de Medicina Integral Professor Fernando Figueira, Recife, Brazil
2Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut
JAMA Pediatr. 2013;167(9):873. doi:10.1001/jamapediatrics.2013.2212.
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In Reply We thank Wang and Shi for their interest in our study and for drawing attention to aspects concerning the number of patients in our study. Initially, we would like to clarify that the Kugelman et al and Sai Sunil Kishore et al studies1,2 included all infants for the definition of bronchopulmonary dysplasia (BPD), while we only included the survivors to 36 weeks’ postmenstrual age. Our trial randomly assigned 100 infants in each group (nasal continuous positive airway pressure and nasal intermittent positive-pressure ventilation)3; however, at 36 weeks we only had 83 infants in the nasal intermittent positive-pressure ventilation group and 80 infants in the nasal continuous positive airway pressure group. Even if we did include all the infants, the results would be very similar (risk ratio, 0.56; 95% CI, 0.09-3.61), with no difference found between the groups and considerable heterogeneity (P = .04; I2 = 70%).


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September 1, 2013
Li Wang, MD; Yuan Shi, MD
1Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing, China
JAMA Pediatr. 2013;167(9):872-873. doi:10.1001/jamapediatrics.2013.2208.
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