The effectiveness of sulfapyridine in the treatment of pneumococcic infections has now been accepted generally. There still remains the problem of determining the best method of administration.
Since the introduction of sulfapyridine for the treatment of pneumonia in children the recommended duration of treatment has steadily decreased, and the estimates of effective levels in the blood have been revised downward. At present the commonly accepted daily dosage is approximately 0.2 Gm. per kilogram of body weight, in divided doses, and the drug is usually given for from two to four days. A level of 4 mg. of free sulfapyridine per hundred cubic centimeters of blood has been accepted as satisfactory, and favorable therapeutic results have been obtained with levels as low as 2 mg. per hundred cubic centimeters.1 The experimental work of Long and Feinstone2 has shown that the excretion of sulfapyridine is slower than that of sulfanilamide.