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Am J Dis Child. 1938;56(5):957-964. doi:10.1001/archpedi.1938.01980170003001.
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In recent years it has been demonstrated that deviations from the normal process of development may occur at certain centers of bone growth in childhood. These changes have been found to take place in the first decade or two of life, before epiphysial ossification has taken place, and may consist of gross irregularities in development, of arrest in normal processes or even of retrogressive changes in the osteochondral portion of the epiphysis of certain bones.

Perthes' disease, involving the head of the femur, Osgood-Schlatter disease, with epiphysial changes in the tibial tuberosity, and vertebral osteochondrosis are classic examples of the osteochondral changes referred to and have been grouped under the head of juvenile epiphysitis or osteochondropathy.

The exact cause of such osteochondral lesions is not known, but apparently they are primary and should be distinguished from acute and chronic epiphysial lesions which are secondary to pathologic processes occurring elsewhere in


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