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Am J Dis Child. 1932;44(5):921-963. doi:10.1001/archpedi.1932.01950120003001.
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The precise nature of the leukocytic reactions during measles still remains a subject concerning which there are surprising differences of opinion. Although it is generally held that a leukocytosis is present during the incubation period, followed as a rule by a leukopenia during the acute febrile stage,1 there is a lack of agreement regarding the changes in the differential count. It was early pointed out by several investigators2 that the fall in the blood count was due chiefly to a diminution in the number of lymphocytes. Diametrically opposed to this finding, however, have been the reports of a lymphocytosis occurring simultaneously with the rash.3 Moreover, it has been maintained4 that variations in the number of polymorphonuclear cells principally account for the leukocytosis or the leukopenia observed in the different phases of the disease. More recent workers,5 on the other hand, have laid great stress on


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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