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EFFECT OF INJECTION OF NONSPECIFIC PROTEIN ON DIPHTHERIA VIRULENCE TESTS IN GUINEA-PIGS

HENRIETTA A. CALHOUN, M.D.
Am J Dis Child. 1921;21(2):107-128. doi:10.1001/archpedi.1921.01910320002001.
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CONTROVERSY CONCERNING THE VALUE OF HORSE SERUM  Bingel,1 noting that toxic cases of diphtheria, in which the most marked effect might be anticipated from antitoxin treatment, react only slightly, questioned the possibility of nonspecific reaction due to a foreign serum. He treated alternating cases of diphtheria entering the hospital with normal horse serum and with antitoxin. He was unable to see any appreciable difference between the 471 horse serum treated cases and the 466 antitoxin treated cases. The bacilli disappeared after four weeks in 89.6 per cent, of the antitoxin treated cases and in 94.6 per cent, of the horse serum cases. He concluded that the success of the serum therapy in diphtheria was dependent on the larger amount of horse serum used with the larger doses of antitoxin. Perhaps Bingel's results with horse serum may be due to the fact that only 45.7 per cent, of his antitoxin

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