Since the publication1 of the first large series of cases of duodenal ulcers in infants in 1909, numerous reports from various clinics and hospitals have appeared which have substantiated the frequent occurrence of duodenal ulcers in infancy. In 1913, Holt2 collected ninety-one cases from the literature and added four more from his clinic. Since that time there have been numerous other publications on the subject which have increased the number of cases reported in the literature, but have not materially enriched our knowledge of the subject. Practically all the publications pass over the etiology of the ulcers with merely a reference to the usual explanations of the incidence of the ulcers as given in the textbooks of pathology (Holt,2 Veeder3).
The etiology of gastric and duodenal ulcer is still a much debated question, so that any information as to its mode of incidence is of value.