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Research Letter |

Effect of Routine Vaccination on Aluminum and Essential Element Levels in Preterm Infants

Tammy Z. Movsas, MD, MPH1,2; Nigel Paneth, MD, MPH2,3; Wilson Rumbeiha, DVM, PhD, DABT, DABVT, VDPAM5; Justin Zyskowski, BA4; Ira H. Gewolb, MD2
[+] Author Affiliations
1Midland County Department of Public Health, Midland, Michigan
2Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan
3Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan
4Diagnostic Center for Population and Animal Health, Michigan State University, East Lansing, Michigan
5College of Veterinary Medicine, Iowa State University, Ames, Iowa
JAMA Pediatr. 2013;167(9):870-872. doi:10.1001/jamapediatrics.2013.108.
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Parenteral feedings containing more than 4 to 5 µg/kg/d of aluminum have been shown to result in neurodevelopmental delay in preterm infants.1 However, an infant at the 2-month checkup receives multiple aluminum-containing vaccines that in combination may have as high as 1225 µg of intramuscular aluminum; this is a much higher intramuscular aluminum dose than the safely recommended intravenous aluminum dose.2 Our first objective was to measure prevaccine and postvaccine levels of aluminum in preterm infants, a population at higher risk of aluminum neurotoxic effects. Our second objective was to measure prevaccine and postvaccine levels of essential elements (EE). Inflammation from trauma can cause declines in serum levels of specific EE such as zinc and selenium35; there may be similar EE perturbations secondary to vaccination-induced inflammation.

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