Editorial |

Vitamin D3 Supplementation to Preserve Pancreatic β-Cell Function in Newly Diagnosed Type 1 Diabetic Patients

Sheela N. Magge, MD, MSCE
Arch Pediatr Adolesc Med. 2012;166(7):664-666. doi:10.1001/archpediatrics.2012.500.
Text Size: A A A
Published online


The prospect of lifelong dependency on exogenous insulin injections and potentially debilitating complications has led scientists to relentlessly search for a cure for type 1 diabetes mellitus (T1DM). As this has proven elusive, attempts to intervene in the disease process have proliferated. In this issue of the Archives, Gabbay et al1 publish the results of a trial attempting to preserve insulin secretory capacity in type 1 diabetic patients. Type 1 diabetes mellitus is characterized by the autoimmune destruction of insulin-producing pancreatic β cells, causing an absolute insulin deficiency. This destruction occurs both before and after clinical disease presentation, and the cause for this immunologic attack is thought to be a combination of both genetic and environmental factors. While genetic predisposition is significant, most individuals with a genetic susceptibility will not develop the disease. It is thought that exposure to a second environmental factor, such as a virus, dietary nutrient, or other antigen, results in disease. The presence of an environmental trigger(s) is supported by the fact that while the prevalence of T1DM varies dramatically in different parts of the world, migrating populations take on the prevalence of their new location relatively quickly.2 It is these potential environmental triggers that have been the target of studies to prevent or intervene in the disease process. Furthermore, the incidence of T1DM has been increasing, particularly in those younger than 5 years,3 adding urgency to our intervention attempts.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics
PubMed Articles