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Am J Dis Child. 1916;XII(3):316-327. doi:10.1001/archpedi.1916.04110150114008.
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The intracutaneous toxin test of Schick for antitoxic immunity in diphtheria may be stated to have definitely established itself as a safe, easily applied and reliable practical test for detecting those persons who have sufficient natural diphtheria antitoxin in their body fluids to protect them against this infection and also as a measure of antitoxin production after active immunization with toxin-antitoxin mixtures, the latter being the original purpose of Schick in working out the technic of this test to replace the more expensive, time consuming and laborious procedure of determining the antitoxin content of a serum by means of injecting mixtures of the serum and a toxin into guinea-pigs.

The positive toxin reaction is a localized inflammation excited by the unneutralized toxin in the skin, and in the majority of instances the area of erythema and edema is sufficiently well marked at the end of forty-eight hours to permit the


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