Orthostatic albuminuria is a comparatively common condition, especially in children, and has been the subject of frequent investigation, yet the pathology of the condition is far from being clearly understood. Although it is not commonly classified among the nephritides, actual opportunities for histologic examination of kidneys from individuals with orthostatic albuminuria, have been very infrequent, chiefly because of the benign character of the affection. Such opportunities for necropsy examination as have occurred have failed to reveal any of the usual pathologic findings of a nephritis. Until the accumulation of necropsy findings or physiologic experimentation shall have cleared up the pathogenesis of the condition, we must rely chiefly on clinical observation and renal tests for our knowledge of the factors involved in its production.
In a clinical investigation, the question of the integrity of the kidney function is naturally one of the first to suggest itself. A few earlier studies of