The incompleteness of our knowledge of the factors controlling calcium metabolism leads us to look for enlightenment to studies of disturbances of bone formation from this point of view. The disease under consideration is preeminently a disturbance of the development and calcification of all the bones of the body. We shall not review the clinical and pathological literature of the subject, as this has been well covered in recent articles.1
CASE REPORT
History.
—A. W., admission number 127,906, history number 258. Admitted Jan. 12, 1912, to the service of Dr. H. Koplik, whom we wish to thank for the privilege of studying this case. Aged 10 weeks on admission.
Family History.
—Russian Jewish parents. Two other children well. Mother had no miscarriages. Negative for tuberculosis and bone disease.
Previous History.
—Normal birth, full term. Breast fed for three weeks, then placed on milk, one-third, water, two-thirds, 3 ounces every