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OSTEOGENESIS IMPERFECTA. REPORT OF A CASE WITH THE STUDY OF ITS METABOLISM

HERMAN SCHWARZ, M.D.; MURRAY H. BASS, M.D.
Am J Dis Child. 1913;V(2):131-142. doi:10.1001/archpedi.1913.04100260044003.
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Osteogenesis imperfecta was one of the diseases which entered into the symptom-complex known as fetal rickets, which gave rise to much discussion during the latter half of the last century. It was Vrolik,1 in 1849, who first described an intra-uterine case in detail and gave it the name of osteogenesis imperfecta. Parrot, in 1878, removed from this group the disease known as achondroplasia, this differentiation being later made more complete by works of Kaufman and his scholars, Dieterlin2 and Schwenderer3 (1899 and 1906). Stilling,4 working under von Recklinghausen, did the first pathologic work, which made osteogenesis imperfecta an entity, and of late the work of Sumita,5 Looser6 and Fuchs7 have continued to emphasize its independent characteristics.

In 1833 Lobstein8 called attention to cases characterized by fragility of the bones and gave them the name osteopsathyrosis, showing that there was among them a

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