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Am J Dis Child. 1911;I(6):431-439. doi:10.1001/archpedi.1911.04100060040003.
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Since Frölich's1 studies of the blood in pertussis in 1897, numerous investigations have been made which show that decided and definite changes occur in the blood as a result of this disease. For the sake of brevity, no attempt will be made at this time to include a review of the literature, the reader being referred to an excellent article by Barach2 and to my own report3 of twenty-seven cases, accompanied by a brief review of the literature and a full bibliography. More recently Donally4 has reported six cases in which leukocyte counts were made. He found a leukocytosis varying in degree from 9,300 on the third day of the disease to 62,000 during the paroxysmal stage. Ashby5 reported also, on examinations of the blood made in 100 cases. He considered leukocytosis itself, which ranged from 15,000 to 30,000 cells per c.c., a valuable aid


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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